CD28 days later: Resurrecting costimulation for CD8(+) memory T cells.
CD28 days later: Resurrecting costimulation for CD8(+) memory T cells.
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CD28 天后：恢复 CD8( ) 记忆 T 细胞的共刺激。
DOI：
10.1002/eji.201646500
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发表时间：
2016
影响因子：
5.4
通讯作者：
Homann,Dirk
中科院分区：
文献类型：
--
作者：
vanderHeide,Verena;Homann,Dirk
抗原再相遇时特异性CD 8+记忆T（CD 8 +TM）细胞的快速活化和增殖扩增是获得性免疫应答的关键组成部分，可增强免疫保护。然而，在这种情况下，共刺激的要求，特别是CD 28信号，仍然不完全确定。在最新一期的《欧洲免疫学杂志》上，Fröhlichet al. [Eur. J. Immunol. 2016.四十六：1644 - 1655]提供了明确的证据，证明CD 8 +TM细胞回忆应答的最佳阐述确实取决于这些细胞表达的CD 28。在这里，我们在其历史背景下讨论“CD 28共刺激范式”，并强调一些与CD 28依赖性相互作用有关的未解决的复杂性，这些相互作用塑造了CD 8 +T细胞表型、功能和回忆反应性。
Rapid activation and proliferative expansion of specific CD8+memory T (CD8+TM) cells upon antigen re‐encounter is a critical component of the adaptive immune response that confers enhanced immune protection. In this context, however, the requirements for costimulation in general, and CD28 signaling in particular, remain incompletely defined. In the current issue of theEuropean Journal of Immunology, Fröhlichet al. [Eur. J. Immunol. 2016. 46: 1644‐1655] provide definitive evidence that optimal elaboration of CD8+TM‐cell recall responses is indeed contingent on CD28 expressed by these cells. Here, we discuss the “CD28 costimulation paradigm” in its historical context and highlight some of the unresolved complexities pertaining to CD28‐dependent interactions that shape CD8+T‐cell phenotypes, functionalities, and recall reactivity.