Altered Molecular Mechanisms of Diabetic Foot Ulcers
Altered Molecular Mechanisms of Diabetic Foot Ulcers
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DOI：
10.1177/1534734609337151
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发表时间：
2009-06-01
影响因子：
1.7
通讯作者：
Jude, Edward B.
中科院分区：
文献类型：
--
作者：
Blakytny, Robert;Jude, Edward B.
全球范围内糖尿病患病率的不断增加将伴随着糖尿病足溃疡发病率的增加，糖尿病足溃疡是一种并发症，其中涉及正常伤口愈合的许多形态过程被破坏。伤口愈合的高度复杂和综合过程受到大量分子因素的调节。它们通常具有重叠的功能，通过冗余确保一定程度的容忍度。在糖尿病中，观察到大量分子因子表达的变化，压倒了这种内在的冗余。这会导致愈合延迟或愈合不完全，如溃疡。了解分子因子水平改变与此类溃疡愈合过程受抑制之间的关系将有助于开发针对性治疗，旨在大大改善患者的生活质量，同时有助于降低与治疗这种糖尿病及其长期后果相关的巨额成本。这篇简短的综述探讨了分子因子表达的变化如何与糖尿病足溃疡的形态改变相关，并非常简要地考虑了分子水平的治疗策略。
The continuously increasing worldwide prevalence of diabetes will be accompanied by a greater incidence of diabetic foot ulcer, a complication in which many of the morphological processes involved in normal wound healing are disrupted. The highly complex and integrated process of wound healing is regulated by a large array of molecular factors. These often have overlapping functions, ensuring a certain degree of tolerance through redundancy. In diabetes, changes to the expression of a large number of molecular factors have been observed, overwhelming this inbuilt redundancy. This results in delayed healing or incomplete healing as in ulceration. Understanding the relationship between altered levels of molecular factors and the inhibited healing process in such ulcers will permit the development of targeted treatments aimed to greatly improve the quality of life of patients, at the same time helping to reduce the huge costs associated with treating this diabetic condition and its long-term consequences. This short review examines how changes in the expression of molecular factors are related to altered morphology in diabetic foot ulceration and very briefly considers treatment strategies at molecular level.