On the evolution of recombination and meiosis.
On the evolution of recombination and meiosis.
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DOI：
10.1017/s001667239800367x
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发表时间：
1999-04
期刊：
影响因子：
--
通讯作者：
D. Gessler;Shizhong Xu
中科院分区：
文献类型：
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作者：
D. Gessler;Shizhong Xu
关于重组进化的理论认为，重组增加平均适合度的能力需要影响适合度的基因座之间负连锁不平衡的一致来源，以显示重组的优势。在这里，我们提出的证据表明，至少在理论上，重组的遗传变异可以在非常大的人群中传播的严格乘法健身，等位基因模型。该模型在多位点环境中仅使用孟德尔遗传学，以表明重组的显性基因在罕见时可以传播，在常见时可以抵抗入侵。在穆勒棘轮驱动的非平衡种群中，基因通过增加与最佳个体相关联的概率来增加其固定概率。这发生在重组的最佳水平。它的作用导致在建模的原减数分裂生物体之间重组的即时和长期优势。遗传机制自然地适合于减数分裂的进化模型，现代配子被视为古代单细胞生物的衍生物。
Theories on the evolution of recombination in regard to its ability to increase mean fitness require a consistent source of negative linkage disequilibrium among loci affecting fitness to show an advantage to recombination. Here we present evidence that, at least theoretically, genetic variation for recombination can spread in very large populations under a strictly multiplicative-fitness, deleterious-allele model. The model uses only Mendelian genetics in a multi-locus context to show that a dominant gene for recombination can spread when rare and resist invasion when common. In non-equilibrium populations driven by Muller's ratchet, the gene increases its probability of fixation by increasing the probability of being associated with the best individuals. This occurs at an optimal level of recombination. Its action results in both an immediate and a long-term advantage to recombination amongst the proto-meiotic organisms modelled. The genetic mechanism lends itself naturally to a model for the evolution of meiosis, where modern-day gametes are seen as derivative of ancient unicellular organisms.