Cholecystokinin and its COOH-terminal octapeptide in the pig brain.
Cholecystokinin and its COOH-terminal octapeptide in the pig brain.
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猪脑中的胆囊收缩素及其COOH末端八肽。
DOI：
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发表时间：
1977
影响因子：
11.1
通讯作者：
R. Yalow
中科院分区：
文献类型：
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作者：
J. Muller;E. Straus;R. Yalow
在猪大脑皮层的提取物中发现了两种成分，一种在大小、电荷和免疫特异性方面类似于完整的胆囊收缩素，另一种类似于胆囊收缩素的COOH末端八肽。提取物中两种肽的相对浓度取决于提取剂，对于完整缩胆囊素的提取，沸腾的 0.1 M HCl 比沸水更有效，但对于八肽的提取效果较差。这些肽在大脑中的生理作用尚未阐明。
Two components--one resembling intact cholecystokinin in size and charge and immunologic specificity, and the other resembling the COOH-terminal octapeptide of cholecystokinin--have been found in extracts of the pig cerebral cortex. The relative concentrations of the two peptides in the extracts were dependent on the extractant, boiling 0.1 M HCl being more effective than boiling water for the extraction of intact cholecystokinin but less effective for the extraction of the octapeptide. The physiologic role of these peptides in the brain has yet to be elucidated.