Roles of Muscularis Mucosae and Myofibroblasts in the Healing Process of Acetic Acid‐Induced Ulcer
Roles of Muscularis Mucosae and Myofibroblasts in the Healing Process of Acetic Acid‐Induced Ulcer
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粘膜肌层和肌成纤维细胞在乙酸诱发的溃疡愈合过程中的作用
DOI：
10.1097/00004836-199001001-00008
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发表时间：
1990
影响因子：
2.9
通讯作者：
M. Tsuchiya
中科院分区：
文献类型：
--
作者：
M. Nakamura;M. Oda;J. Inoue;Y. Nishizaki;M. Tsuchiya
在对照组和乙酸处理的大鼠胃底粘膜中，研究了FITC-鬼笔环肽阳性平滑肌细胞和间质细胞的定位变化。在对照组大鼠中，FITC-鬼笔环肽阳性细胞主要对应于粘膜肌层的平滑肌细胞以及小动脉和小静脉平滑肌细胞。另一方面，乙酸处理后1周，粘膜肌层平滑肌细胞的荧光消失，再生粘膜层中出现大量可能对应于肌成纤维细胞的荧光间质细胞。应用后3周，形成了严重增厚的荧光粘膜肌层，间质细胞的荧光明显减弱。
The changes in the localization of FITC-phalloidin-positive smooth muscle cells and interstitial cells were studied in control and acetic acid-treated rat fundic mucosa. In the Control rats, the FITC-phalloidin-positive cells mostly corresponded to the smooth muscle cells of the muscularis mucosae, and the arteriolar and venular smooth muscle cells. On the other hand, I week after the acetic acid treatment, the fluorescence of the smooth muscle cells of the muscularis mucosae disappeared and a large number of fluorescent interstitial cells, probably corresponding to myofibroblasts, appeared in the regenerated mucosal layer. Three weeks after the application, severely thickened fluorescent muscularis mucosae were formed and the fluorescence of the interstitial cells was rather decreased.