CHK it out! Blocking WEE kinase routs TP53 mutant cancer.
CHK it out! Blocking WEE kinase routs TP53 mutant cancer.
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DOI：
10.1158/1078-0432.ccr-14-0720
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发表时间：
2014-08-15
期刊：
影响因子：
--
通讯作者：
Chung CH
中科院分区：
文献类型：
--
作者：
Bauman JE;Chung CH
编码主要肿瘤抑制因子p53的TP53突变由于无法靶向功能丧失而导致了发育治疗困境。抑制WEE1或CHK1激酶（G2 - m检查点的负调节因子），选择性地使p53缺陷细胞对外源DNA损伤敏感，取消G2阻滞并加速有丝分裂灾难。
Mutations in TP53, encoding the master tumor suppressor p53, have posed a developmental therapeutic dilemma due to inability to target loss of function. Inhibition of WEE1 or CHK1 kinase, negative regulators of the G2–M checkpoint, selectively sensitizes p53-deficient cells to exogenous DNA damage, abrogating G2 arrest and precipitating mitotic catastrophe.