Traditional Chinese medicine use is associated with lower risk of pneumonia in patients with systemic lupus erythematosus: a population-based retrospective cohort study.
Traditional Chinese medicine use is associated with lower risk of pneumonia in patients with systemic lupus erythematosus: a population-based retrospective cohort study.
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DOI：
10.3389/fphar.2023.1185809
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发表时间：
2023
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
目的：探讨系统性红斑狼疮(SLE)患者中医药治疗与肺炎风险的关系。方法：这项以人群为基础的对照研究分析了台湾国家健康保险研究数据库中的数据。从2000-2018年期间的200万份记录中，最初纳入了9714名新诊断的系统性红斑狼疮患者。532例肺炎患者和532例非肺炎患者按年龄、性别和SLE诊断年份进行1：1匹配。从SLE诊断日到指标日考虑中医药治疗的使用情况，并用中医药治疗的累计天数计算剂量效应。采用条件Logistic回归分析肺炎感染的危险因素。此外，为了探讨SLE患者肺炎的严重性，采用急诊室就诊、入院时间和抗生素使用等参数对分层后的敏感性进行了分析。结果：中医药治疗60天可显著降低系统性红斑狼疮患者发生肺炎的风险(95%CI=0.46~0.91；P=0.012)。分层分析显示，使用中药还可以将年轻SLE患者和女性SLE患者患肺炎的风险分别降低34%和35%。中医治疗60天可显著降低2、3、7、8年随访期肺炎的风险。此外，在因中度或重度肺炎而接受抗生素治疗的SLE患者中，暴露于中医药60天的患者患肺炎的风险降低。最后，研究发现，补肾方剂使用时间超过90天，方剂使用活血时间在30天以内，可显著降低SLE患者肺炎感染风险。结论：在系统性红斑狼疮患者中，使用中药与肺炎风险降低有关。
Objectives: To investigate the association between traditional Chinese medicine (TCM) therapy and the risk of pneumonia in patients with systemic lupus erythematosus (SLE). Methods: This population-based control study analyzed the data retrieved from the National Health Insurance Research database in Taiwan. From a cohort of 2 million records of the 2000–2018 period, 9,714 newly diagnosed patients with SLE were initially included. 532 patients with pneumonia and 532 patients without pneumonia were matched 1:1 based on age, sex, and year of SLE diagnosis using propensity score matching. The use of TCM therapy was considered from the SLE diagnosis date to the index date and the cumulative days of TCM therapy were used to calculate the dose effect. Conditional logistic regression was used to investigate the risk of pneumonia infection. Furthermore, to explore the severity of pneumonia in SLE, sensitivity analyses were performed after stratification using the parameters of emergency room visit, admission time, and antibiotic use. Results: TCM therapy for >60 days could significantly reduce the risk of pneumonia in patients with SLE (95% CI = 0.46–0.91; p = 0.012). Stratified analysis showed that TCM use also reduced the risk of pneumonia in younger and female patients with SLE by 34% and 35%, respectively. TCM for >60 days significantly reduced the risk of pneumonia in the follow-up periods of >2, >3, >7, and >8 years. In addition, the exposure of TCM for >60 days reduced the risk of pneumonia in patients with SLE who were treated with antibiotics for moderate or severe pneumonia. Finally, the study found that using formulae to tonify the kidney for more than 90 days and formulae to activate blood circulation for less than 30 days could significantly reduce the risk of pneumonia infection in patients with SLE. Conclusion: TCM use is associated with a lower risk of pneumonia among patients with SLE.
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DOI：
10.1155/2021/5541228
发表时间：
2021
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
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作者：
Liu LC;Mao QY;Liu C;Hu J;Duan L;Wang J
通讯作者：
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影响因子：
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作者：
Andrade, Rosa M.;Alarcon, Graciela S.;Reveille, John D.
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DOI：
10.1093/rheumatology/keaa188
发表时间：
2020-11-01
期刊：
Rheumatology (Oxford, England)
影响因子：
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作者：
Kedves M;Kósa F;Kunovszki P;Takács P;Szabó MZ;Karyekar C;Lofland JH;Nagy G
通讯作者：
Nagy G
DOI：
10.26355/eurrev_202009_23060
发表时间：
2020-01-01
影响因子：
3.3
作者：
Bonometti, R.;Sacchi, M. C.;Boverio, R.
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影响因子：
5.6
作者：
Ji, Lina;Fan, Xuemin;Li, Rongqun
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