The inhibition of superoxide anion generation by neutrophils from Viscum articulactum
The inhibition of superoxide anion generation by neutrophils from Viscum articulactum
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DOI：
10.1248/cpb.52.858
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发表时间：
2004-07-01
影响因子：
1.7
通讯作者：
Chiu, ST
中科院分区：
文献类型：
--
作者：
Leu, YL;Kuo, SM;Chiu, ST
两个新的黄烷酮，（2S）-松属素7-O-[β-D-阿朴糖基（1->2）]-β-D-葡萄糖苷（1）和（2，S）-松属素7-O-[肉桂酰基（1->5）-β-D-阿朴糖基（1->2）]-β-D-葡萄糖苷（2），以及十八个已知的化合物，包括五个已知的黄烷酮，九个苯并吡喃，一个肌醇和三个三萜类化合物，从新鲜槲寄生中分离并鉴定了其结构。新化合物的结构经波谱分析确定。其中，油酸（18）对人中性粒细胞响应甲酰-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸（fMLP）产生超氧阴离子显示出显著的抑制作用。
Two new flavanones, (2S)-pinocembrin 7-O-[beta-D-apiosyl(1-->2)]-beta-D-glucoside (1), and (2,S)-pinocembrin 7-O-[cinnamoyl(1-->5)-beta-D-apiosyl(1-->2)]-beta-D-glucoside (2) together with eighteen known compounds, which include five known flavanones, nine benzenoids, one inositol and three triterpenoids, were isolated and characterized from fresh Viscum articulactum. Structures of new compounds were determined by spectral analysis. Among them, oleanolic acid (18) showed a significant inhibition effect on superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).