The interleukin-6-174G/C promoter polymorphism is not associated with endometriosis in south Indian women
The interleukin-6-174G/C promoter polymorphism is not associated with endometriosis in south Indian women
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DOI：
10.1016/j.jsgi.2005.03.005
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发表时间：
2005-07-01
期刊：
影响因子：
--
通讯作者：
Shivaji, S
中科院分区：
文献类型：
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作者：
Bhanoori, M;Babu, KA;Shivaji, S
目的：研究白细胞介素6（IL-6）基因启动子-174 G/C多态性与南印度妇女子宫内膜异位症的关系。方法：采用聚合酶链反应（PCR）和测序分析方法，比较了患有子宫内膜异位症（h = 232）和不患有子宫内膜异位症（n = 210）的不孕症患者中常见IL-6 - 174 G/C多态性的基因型频率。病例组和对照组的基因型频率分别为G/G 62.9%和71.9%，G/C 34.1%和25.2%，C/C 3.0%和2.9%。G和C等位基因频率分别为80%和84.6%，20%和15.4%。病例和对照组之间的基因型分布或等位基因频率无统计学显著差异（P = 0.12）。结论：本研究表明IL-6 - 174 G/C启动子多态性与南印度妇女子宫内膜异位症之间无显著相关性。
OBJECTIVE: To investigate the association of the - 174 G/C promoter polymorphism of the interleukin-6 (IL-6) gene with endometriosis in South Indian women.METHODS: The genotype frequencies of the common IL-6 - 174 G/C polymorphism were compared in infertility patients with (h = 232) and without (n = 210) endometriosis using polymerase chain reaction (PCR) and sequencing analysis.RESULTS: The genotype frequencics among the cases and controls were G/G 62.9% and 71.9%, G/C 34.1% and 25.2%, and C/C 3.0% and 2.9%. The G and C allele frequencies were 80% and 84.6%, and 20% and 15.4%, respectively. There were no statistically significant differences in the genotype distributions or allele frequencies between the cases and controls (P =.12).CONCLUSIONS: The present study demonstrates no significant association between the IL-6 - 174 G/C promoter polymorphism and endometriosis in South Indian women.Copyright (c) 2005 by the Society for Gynecologic Investigation.