Adverse response to methylphenidate in combination with valproic acid.
Adverse response to methylphenidate in combination with valproic acid.
复制标题
哌醋甲酯与丙戊酸合用时出现不良反应。
DOI：
10.1089/cap.2000.10.39
复制
发表时间：
2000
影响因子：
1.9
通讯作者：
W. Roberts
中科院分区：
文献类型：
--
作者：
L. Gara;W. Roberts
有注意力缺陷多动障碍(ADHD)症状的癫痫儿童正在接受联合使用哌醋甲酯(MPH)和抗癫痫药物。我们报告了两例服用丙戊酸的儿童服用MPH后出现运动障碍和磨牙症的不良反应。这些不良反应迅速而严重。由于这种联合用药可能会产生严重和持续的副作用，因此在服用丙戊酸的儿童使用MPH治疗ADHD时需要谨慎。需要对丙戊酸和mph的联合使用进行进一步的前瞻性研究。
The use of methylphenidate (MPH) in combination with antiepileptic drugs is gaining acceptance for children with epilepsy who have the symptoms of attention-deficit hyperactivity disorder (ADHD). We report two cases of an adverse effect of dyskinesia and bruxism when MPH was given to children maintained on valproic acid. These adverse effects were rapid and severe. Because of the potential for serious and persistent side effects from this combination of medications, caution is warranted in the treatment of ADHD with MPH for children taking valproic acid. Further prospective studies of the use of valproic acid and MPH in combination are required.