Changes in neurotransmitter metabolism following olfactory bulbectomy in the rat
Changes in neurotransmitter metabolism following olfactory bulbectomy in the rat
复制标题
大鼠嗅球切除术后神经递质代谢的变化
DOI：
10.1016/0278-5846(84)90163-5
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发表时间：
1984
影响因子：
5.6
通讯作者：
B. Leonard
中科院分区：
文献类型：
--
作者：
S. Jancsár;B. Leonard
双侧嗅球消融导致大鼠大脑杏仁核皮质和中脑区域的几种神经递质的“周转”发生显着变化。抑制酪氨酸和色氨酸羟化酶后，球切除大鼠杏仁核皮质中去甲肾上腺素和血清素浓度的下降并不像对照组那么明显。这表明球茎切除术后这些生物胺的“周转”减少。 GABA 转氨酶抑制后，与对照组相比，该区域 GABA 浓度增加，从而表明抑制性神经递质的“周转”增强，杏仁核皮质中谷氨酸脱羧酶活性也增加。中脑中去甲肾上腺素或血清素的“周转”没有变化，但多巴胺的周转以及谷氨酸脱羧酶的活性均下降。结论是，这些大脑区域中神经递质“周转”的变化可归因于嗅球的破坏，并可能导致我们和其他人在其他地方报道过的行为缺陷。
Bilateral ablation of the olfactory bulbs caused marked changes in the'turnover'of several neurotransmitters in the amygdaloid cortex and the mid-brain areas of the rat brain. Following tyrosine and tryptophan hydroxylase inhibition, the decrease in the concentration of noradrenaline and serotonin respectively in the amygdaloid cortex was not so marked in the bulbectomized rats as in their controls. This suggests that the'turnover'of these biogenic amines is reduced following bulbectomy. Following GABA transaminase inhibition, the increase in the concentration of GABA in this region was increased compared to the controls thereby suggesting that the'turnover'of the inhibitory neurotransmitter was enhanced, glutamate decarboxylase activity was also increased in the amygdaloid cortex. No changes were found in the'turnover'of noradrenaline or serotonin in the mid-brain but that of dopamine was decreased as was the activity of glutamate decarboxylase. It is concluded that changes in neurotransmitter'turnover'in these brain regions are attributable to the destruction of the olfactory bulbs and may contribute to the behavioural deficits which we, and others, have reported elsewhere.