SERUM CREATINE-KINASE ISOENZYMES IN DUCHENNE MUSCULAR-DYSTROPHY DETERMINED BY SENSITIVE ENZYME-IMMUNOASSAY METHODS
SERUM CREATINE-KINASE ISOENZYMES IN DUCHENNE MUSCULAR-DYSTROPHY DETERMINED BY SENSITIVE ENZYME-IMMUNOASSAY METHODS
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DOI：
10.1002/mus.880100513
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发表时间：
1987-06-01
期刊：
影响因子：
3.4
通讯作者：
OSUGI, S
中科院分区：
文献类型：
--
作者：
MOKUNO, K;RIKU, S;OSUGI, S
应用酶免疫分析法（EIA）测定50例假肥大型肌营养不良症（DMD）患者和39例正常人血清肌酸激酶（CK）同工酶（MM、MB和BB）水平。DMD患者血清MM、MB、BB水平均高于对照组，且随年龄增长而降低。血清MB水平与血清碳酸酐酶III（CA-III）水平具有良好的相关性，但与心电图结果相关性较差，表明DMD患者血清MB的主要来源是骨骼肌而不是心肌。
Serum levels of creatine kinase (CK) isoenzymes (MM, MB, and BB) were measured by sensitive enzyme immunoassay (EIA) methods in 50 patients with Duchenne muscular dystrophy (DMD) and in 39 controls. MM, MB, and BB levels in DMD patients were higher than in controls, and these three levels decreased with advancing age of DMD patients. Serum MB levels showed a good correlation with serum levels of carbonic anhydrase III (CA-III), but correlated poorly with electrocardiographic findings, suggesting that the main origin of serum MB in DMD is skeletal muscle rather than cardiac muscle.