Correlation between Acute Reductions in Myocardial Blood Flow and Function in Conscious Dogs
Correlation between Acute Reductions in Myocardial Blood Flow and Function in Conscious Dogs
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DOI：
10.1161/01.res.47.2.201
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发表时间：
1980-08
影响因子：
20.1
通讯作者：
S. Vatner
中科院分区：
文献类型：
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作者：
S. Vatner
对14只急性分级冠脉狭窄的清醒犬进行了局部心内膜功能(超声测量技术)和血流量(放射性微球技术)的相关性研究。冠脉狭窄对整体心功能的影响很小，但导致缺血区局部血流量(BF)和节段长度(SL)逐渐缩短。SL(%Δ)=-161.6 e−0.047BF(%Δ)(r=0.92)。14个节段功能无变化，血流量下降6±1%。然而，血流量减少10%-20%会显著损害功能。严重的血流量减少才能使功能完全丧失。在12个运动异常的节段中，血流下降了95±2%，比无运动的4个节段(−82±4%)大(P<；0.01)。这些数据表明，一方面血流量只减少10%-20%就会严重损害功能，另一方面，要完全取消主动缩短，需要血流量的严重减少，这表明急性心肌缺血清醒的狗的血流量和功能之间存在敏感的耦合。中国保监会第47：201-207号决议，1980年
Decreases in regional endocardia] function (ultrasonic dimension technique) and blood flow (radioactive microsphere technique) were correlated in 14 conscious dogs with acute graded levels of coronary stenosis. Coronary stenosis affected overall ventricular function only slightly, but induced gradual reductions in regional blood flow (BF) and segment length (SL) shortening in the ischemic zone. The relationship was best fit by an exponential function relating % change in SL to % change in BF; i.e., SL(%Δ) = -161.6 e−0.047BF(%Δ) (r = 0.92). In 14 segments, where no change in function was observed, blood flow fell by 6 ± 1%. However, 10-20% reductions of blood flow impaired function significantly. Severe reduction of blood flow was required to reduce function completely. In 12 segments exhibiting paradoxical motion, blood flow fell by 95 ± 2%, a value greater(P < 0.01) than in four akinetic segments, i.e., those with no shortening or lengthening (−82 ± 4%). These data, which show on one hand that only 10-20% reductions in blood flow impair function significantly and that, on the other hand, severe reductions in blood flow are required to abolish active shortening completely, indicate sensitive coupling between blood flow and function in the conscious dog with acute myocardial ischemia. Circ Res 47: 201-207, 1980