Elimination from the body of tobacco products by smokers and passive smokers.
Elimination from the body of tobacco products by smokers and passive smokers.
复制标题
吸烟者和被动吸烟者从体内消除烟草制品。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
D. Hoffmann
中科院分区：
文献类型：
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作者：
D. Sepkovic;N. Haley;D. Hoffmann
致编辑。-流行病学研究表明，接触环境烟雾与烟草相关疾病有关。烟草侧流烟雾的成分与主流烟雾的成分有很大不同。N -亚硝胺、苯并[a]芘、一氧化碳、尼古丁和重金属在侧流中比在主流烟雾中含量更多。5 .在严重污染的环境中接触这类有害化合物可能对被动接触者构成健康风险。通过测量血浆和尿液中的可替宁，我们估计了吸烟者和被动接触尼古丁的非吸烟者体内这种尼古丁代谢的最终产物的消除率。十个吸烟者每天上午九点半到诊所报到抽血。第五天中午，受试者戒烟。从第5天到第12天每天采集血液样本。在整个研究期间，每天收集所有的尿液。四名年龄在25至35岁之间的非吸烟者，
To the Editor.— Epidemiologic studies have indicated an association of environmental smoke exposure with tobacco-related disease. 1-4 The composition of tobacco sidestream smoke differs significantly from that of mainstream smoke. N -nitrosamines, benzo[ a ]pyrene, carbon monoxide, nicotine, and heavy metals are more abundant in sidestream than in mainstream smoke. 5 Exposure to such harmful chemical compounds in heavily polluted environments may constitute a health risk to passively exposed individuals. By measuring cotinine in plasma and in urine, we have estimated the rate of elimination of this end product of nicotine metabolism in both smokers and passively exposed nonsmokers. Ten smokers reported to the clinic each day at 9:30 AM for blood sampling. At noon on day 5, the subjects quit smoking. Blood samples were taken daily from day 5 through day 12. All urine voided was collected daily throughout the study period. Four nonsmokers, aged 25 to 35 years,
影响因子：
11.2
作者：
D. Hoffmann;S. Hecht
通讯作者：
D. Hoffmann;S. Hecht