Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors
Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors
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DOI：
10.1038/nn1974
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发表时间：
2007-10-01
影响因子：
25
通讯作者：
Sewell, William F.
中科院分区：
文献类型：
--
作者：
Chen, Zhiqiang;Kujawa, Sharon G.;Sewell, William F.
我们报告了一个强大的调节表面AMPA受体在小鼠听觉神经元中，无论是在培养的神经元中的应用程序的谷氨酸受体激动剂，并在体内的声刺激。声刺激后表面AMPA受体的可逆减少与声敏感性的变化相关。因此，我们表明，AMPA受体循环是重要的优化突触传递在体内最严格的突触之一。
We report a robust regulation of surface AMPA receptors in mouse auditory neurons, both with application of glutamate receptor agonists in cultured neurons and in response to acoustic stimulation in vivo. The reversible reduction of surface AMPA receptors following acoustic stimulation correlated with changes in acoustic sensitivity. Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body.