The conformation, flexibility, and dynamics of polypeptide hormones.

The conformation, flexibility, and dynamics of polypeptide hormones.
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多肽激素的构象、灵活性和动力学。

DOI:
10.1146/annurev.bi.51.070182.001011
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发表时间:
1982
影响因子:
16.6
通讯作者:
S. Wood
S. Wood
中科院分区:
生物学1区
文献类型:
--
作者:
T. Blundell;S. Wood

文献摘要

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观点和总结... 123胰岛素样多肽126晶体中的胰岛素结构126溶液中的胰岛素结构130胰岛素样多肽131胰岛素-类生长因子和松弛素132胰岛素在储存和受体上的结构134生长激素家族136糖蛋白激素137胰多肽138晶体结构138溶液中的结构139胰高血糖素家族140胰高血糖素140的晶体结构胰高血糖素140的晶体结构141胶束结合的胰高血糖素; 143分泌素143储存颗粒中的胰高血糖素和受体144神经垂体激素145生长抑素147内啡肽和促肾上腺皮质激素家族148结论
PERSPECTIVES AND SUMMARY ......... 123 INSULIN-LIKE POLYPEPTIDES 126 Insulin Structures in Crystals 126 Insulin Structure in Solution 130 Hystricomorph Insulins 131 Insulin-like Growth Factors and Relaxins 132 Insulin Structure in Storage and at the Receptor 134 GROWTH HORMONE FAMILy 136 GLYCOPROTEIN HORMONES 137 PANCREATIC POLYPEPTIDE 138 Crystal Structure 138 Structure in Solution 139 GLUCAGON FAMILY 140 Crystal Structure of Glucagon 140 Solution Structure of Glucagon ..... 141 Micelle-Bound Glucagon ; 143 Secretin 143 Glucagon in Storage Granules and at the Receptor 144 NEUROHYPOPHYSEAL HORMONES 145 SOMATOSTATIN 147 ENDORPHIN AND ADRENOCORTICOTROPIN FAMILIES 148 CONCLUSIONS 150