The clinical significance of electrophysiological measures of olfactory function
The clinical significance of electrophysiological measures of olfactory function
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DOI：
10.1016/j.bbr.2006.02.013
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发表时间：
2006-06-03
影响因子：
2.7
通讯作者：
Hummel, Thomas
中科院分区：
文献类型：
--
作者：
Loetsch, Joern;Hummel, Thomas
目的：为了建立嗅觉事件相关电位（OERP）的可检测性，从嗅觉function.Methods的心理物理测试的结果：59名男性和64名女性（年龄19-89岁）参加了所有的人提出了自己的一个专门的“嗅觉和味觉诊所”，因为chemosensory投诉。通过心理物理测试评估他们的嗅觉功能，例如，气味阈值、气味辨别和气味识别的评估，将其组合在复合“阈值辨别识别”评分（“TDI评分”）中。OERP获得嗅觉刺激剂苯乙醇的反应，他们的存在/不存在由一个训练有素的观察员判断。使用逻辑回归TDI得分计算有关的受试者的嗅觉功能，OERP的存在的概率变得大于chance.Results：基于心理物理测试，40名受试者被诊断为功能性嗅觉丧失，40与嗅觉减退，和43名受试者得分在正常范围内。嗅觉减退和嗅觉丧失的原因包括先天性嗅觉丧失、帕金森病、头部创伤、上呼吸道感染和鼻窦疾病。TDI评分为22.6，相当于“明显嗅觉减退”，被确定为OERP检测概率高于50%的转折点。其95%置信区间为16.1-27.8，很好地反映了嗅觉减退的范围，即，结论：在嗅觉功能正常和功能性嗅觉缺失的范围内，OERP的检出率大于50%，OERP的检出率大于50%。OERP的存在清楚地表明嗅觉功能的存在，而OERP的缺乏并不总是相反。(c)2006 Elsevier B. V.保留所有权利。
Aim: To establish the detectability of olfactory event-related potentials (OERP) in relation to-the results from psychophysical tests of olfactory function.Methods: Fifty-nine men and 64 women (aged 19-89 years) participated all of whom presented themselves to a specialized "Smell and Taste Clinic" because of chemosensory complaints. Their olfactory function was assessed by means of psychophysical tests, e.g., assessment of odor threshold, odor discrimination, and odor identification, which were combined in a composite "Threshold Discrimination Identification" score ("TDI score"). OERP were obtained in response to the olfactory stimulant phenyl ethyl alcohol; their presence/absence was judged by a trained observer. Using logistic regression the TDI score was calculated in relation to the subjects' olfactory function at which the probability of the presence of OERP became greater than chance.Results: Based on psychophysical tests, 40 subjects were diagnosed with functional anosmia, 40 with hyposmia, and 43 subjects scored within the normal range. Causes of hyposmia and anosmia included congenital anosmia, Parkinson's disease, head trauma, infections of the upper respiratory tract, and sinunasal disease. A TDI score of 22.6 equivalent to "pronounced hyposmia" was identified as the turning point at which the probability of detection of OERP was higher than 50%. Its 95% confidence interval of 16.1-27.8 well reflected the range of hyposmia, i.e., was above significant loss of olfactory function (functional anosmia, TDI score < 15.5) and below normal olfactory function (TDI score > 30.5).Conclusion: The present results indicate that the probability to detect an OERP becomes greater than 50% within a range of olfactory function that separates functional anosmia from normosmia. Presence of OERP clearly signifies presence of olfactory function while this is not always the other way around with absence of OERP. (c) 2006 Elsevier B.V. All rights reserved.