exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes.
exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes.
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exoRBase：人类血液外泌体中circRNA、lncRNA和mRNA的数据库
DOI：
10.1093/nar/gkx891
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发表时间：
2018-01-04
影响因子：
14.9
通讯作者：
Huang S
中科院分区：
文献类型：
--
作者：
Li S;Li Y;Chen B;Zhao J;Yu S;Tang Y;Zheng Q;Li Y;Wang P;He X;Huang S
摘要胞外体是由大多数细胞分泌的纳米大小的内吞囊泡，含有丰富的不同种类的RNA，可以调节受体细胞的行为，可以作为疾病的循环生物标志物。在这里，我们开发了一个可在网络上访问的数据库(http://www.exoRBase.org)，exoRbase)，它是从人类血液外切体的rna-seq数据分析中获得的环状rna(环状rna)、长非编码rna(Lncrna)和信使rna(Mna)的储存库。对已发表文献的实验验证也包括在内。ExoRBase的特点是基于横跨正常人和不同疾病患者的标准化RNA-SEQ数据，整合和可视化RNA表达谱。ExoRBase的目标是收集和鉴定人类血液外切体中的所有长RNA物种。首次发布的exoRBase包含58330个CircRNAs、15501个lncRNAs和18333mRNAs。提供了注释、表达水平和可能的原始组织。ExoRBase将帮助研究人员识别血液外切体中的分子特征，并将引发新的外切体生物标记物的发现和对人类疾病的功能暗示。
Abstract Exosomes, which are nanosized endocytic vesicles that are secreted by most cells, contain an abundant cargo of different RNA species that can modulate the behavior of recipient cells and may be used as circulating biomarkers for diseases. Here, we develop a web-accessible database (http://www.exoRBase.org), exoRBase, which is a repository of circular RNA (circRNA), long non-coding RNA (lncRNA) and messenger RNA (mRNA) derived from RNA-seq data analyses of human blood exosomes. Experimental validations from the published literature are also included. exoRBase features the integration and visualization of RNA expression profiles based on normalized RNA-seq data spanning both normal individuals and patients with different diseases. exoRBase aims to collect and characterize all long RNA species in human blood exosomes. The first release of exoRBase contains 58 330 circRNAs, 15 501 lncRNAs and 18 333 mRNAs. The annotation, expression level and possible original tissues are provided. exoRBase will aid researchers in identifying molecular signatures in blood exosomes and will trigger new exosomal biomarker discovery and functional implication for human diseases.