CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis.
CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis.
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DOI：
10.1186/1476-5926-6-4
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发表时间：
2007-05-01
期刊：
影响因子：
--
通讯作者：
Kopchick JJ
中科院分区：
文献类型：
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作者：
Kelder B;Boyce K;Kriete A;Clark R;Berryman DE;Nagatomi S;List EO;Braughler M;Kopchick JJ
由胰岛素抵抗和脂肪细胞脂解增加引起的循环脂肪酸水平增加可在肝脏内积聚，导致脂肪变性。这种脂肪变性使肝脏对炎症和进一步的损伤敏感，这可能导致肝功能障碍。我们对不同年龄的正常小鼠肝脏组织和表现出脂肪变性的2型糖尿病肝脏进行了微阵列分析，以确定参与脂质积聚和肝功能障碍的差异表达基因。微阵列分析确定CIDE-A作为年龄函数的最差异表达基因。喂食高脂肪饮食的小鼠出现高胰岛素血症、高血糖症和肝脏脂肪变性，这些都是人类代谢综合征的特征。CIDE-A在2型糖尿病肝脏中表达增加，体重减轻和血浆胰岛素正常化可逆转CIDE-A表达升高。此外，发现CIDE-A表达与肝脏脂质蓄积相关。CIDE-A表达随高胰岛素血症和肝脏脂肪变性的相应增加表明肝脏中脂质蓄积的新途径。
Increased levels of circulating fatty acids caused by insulin resistance and increased adipocyte lipolysis can accumulate within the liver resulting in steatosis. This steatosis sensitizes the liver to inflammation and further injury which can lead to liver dysfunction. We performed microarray analysis on normal mouse liver tissue at different ages and type 2 diabetic liver exhibiting steatosis to identify differentially expressed genes involved in lipid accumulation and liver dysfunction. Microarray analysis identified CIDE-A as the most differentially expressed gene as a function of age. Mice fed a high fat diet developed hyperinsulinemia, hyperglycemia and liver steatosis, all features of the human metabolic syndrome. Increased CIDE-A expression was observed in type 2 diabetic liver and the elevated CIDE-A expression could be reversed by weight loss and normalization of plasma insulin. Also, CIDE-A expression was found to be correlated with hepatic lipid accumulation. The corresponding increase in CIDE-A expression with hyperinsulinemia and liver steatosis suggests a novel pathway for lipid accumulation in the liver.