Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010
Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010
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DOI：
10.1183/09031936.00061611
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发表时间：
2012-04-01
影响因子：
24.3
通讯作者：
Verlato, G.
中科院分区：
文献类型：
--
作者：
de Marco, R.;Cappa, V.;Verlato, G.
直到 20 世纪 90 年代，全球哮喘患病率一直在上升，但此后并没有明确的时间模式。本研究旨在评估 1990 至 2010 年间意大利成年人当前哮喘、哮喘样症状和过敏性鼻炎患病率的时间趋势。在三项多中心研究的框架内，通过邮寄或电话对意大利一般人群（20-44 岁）的随机样本进行了相同的筛查调查问卷：欧洲共同体呼吸健康调查(ECRHS) (1991-1993；n=6,031)；意大利年轻人哮喘研究 (ISAYA)（1998-2000 年；n=18,873）；呼吸道疾病基因环境相互作用 (GEIRD) 研究（2007-2010；n=10,494）。在不同时间点重复调查的中心，使用泊松回归模型估计了患病率的时间趋势。从1991年到2010年，当前哮喘、喘息和过敏性鼻炎的中位患病率分别从4.1%增加到6.6%，从10.1%增加到13.9%，从16.8%增加到25.8%。目前哮喘的患病率在 20 世纪 90 年代保持稳定，但从 1998-2000 年到 2007-2010 年有所增加（相对风险 1.38，95% CI 1.19-1.59），主要发生在没有报告过敏性鼻炎的受试者中。自1991年以来，过敏性鼻炎的患病率持续上升。意大利的哮喘流行尚未结束。在过去 20 年中，哮喘患病率增加了 38%，与此同时，哮喘样症状和过敏性鼻炎也有类似的增加。
The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern.The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010.The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993; n=6,031); the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000; n=18,873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010; n=10,494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time.From 1991 to 2010, the median prevalence of current asthma, wheezing and allergic rhinitis increased from 4.1% to 6.6%, from 10.1% to 13.9% and from 16.8% to 25.8%, respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38, 95% CI 1.19-1.59) from 1998-2000 to 2007-2010, mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991.The asthma epidemic is not over in Italy. During the past 20 yrs, asthma prevalence has increased by 38%, in parallel with a similar increase in asthma-like symptoms and allergic rhinitis.