Stages of increased cerebral blood flow accompany stages of rapid brain growth
Stages of increased cerebral blood flow accompany stages of rapid brain growth
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DOI：
10.1016/s0387-7604(99)00066-2
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发表时间：
1999-12-01
影响因子：
1.7
通讯作者：
Epstein, HT
中科院分区：
文献类型：
--
作者：
Epstein, HT
大脑快速发育阶段的存在意味着相关阶段脑血流量(CBF)的存在，以供应增加的大脑重量所需的物质和能量。文献中的研究给出了人类脑血流的发育数据，这些数据表明，在大脑快速发育阶段之前和/或同时开始的年龄，脑血流增加的阶段。在PET数据中也发现了对最早阶段之一的暗示的确认。另外。啮齿类动物的数据显示，脑血流量增加的阶段与它们的大脑发育阶段有类似的关联。因此，对于数据的准确性来说，这一含意得到了证实。发现大脑血流的不同阶段预示着大脑发育阶段的存在。此外，发现相关的血液流动阶段也支持这两个物种大脑快速发育阶段的年龄跨度。这种相关性还表明，对体内任何地方的血流进行测量可能有助于揭示特定部位或器官的快速生长阶段。大脑消耗的能量占全身能量的比例从出生时的近100%下降到18岁时约20%的成人值。(C)1999 Elsevier Science B.V.保留所有权利。
The existence of stages of rapid brain growth implies the existence of associated stages of increased cerebral blood flow (CBF) to supply the substances and energy needed for the added brain weight. Studies in the literature give developmental data for CBF in humans which show stages of increased cerebral blood flow at ages starting just preceding and/or coincident with the ages of the rapid brain growth stages. Confirmation of the implication for one of the earliest stages is also found in PET data. Additionally. data for rodents show a similar association of stages of increasing CBF and their brain growth stages. Thus, to the accuracy of the data, the implication is confirmed. Finding stages in cerebral blood flow predicts the existence of stages of brain growth. In addition; finding correlated blood flow stages also supports the age spans of the stages of rapid brain growth in both species. Such correlations also suggest that measurements of blood flow anywhere in the body might serve to reveal rapid growth stages in particular localities or organs ii the blood flow shows significant stages. The ratio of energy consumed in brain to that in total body decreases from close to 100% at birth to the adult value of about 20% by age 18 years. (C) 1999 Elsevier Science B.V. All rights reserved.