Comprehensive analysis of common safety profiles and their predictive factors in 520 records of liver cancer patients treated by drug-eluting beads transarterial chemoembolization.
Comprehensive analysis of common safety profiles and their predictive factors in 520 records of liver cancer patients treated by drug-eluting beads transarterial chemoembolization.
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综合分析 520 例接受药物洗脱珠经动脉化疗栓塞治疗的肝癌患者的常见安全性及其预测因素。
DOI：
10.1097/md.0000000000011131
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发表时间：
2018-06
期刊：
影响因子：
1.6
通讯作者：
Zheng S
中科院分区：
文献类型：
--
作者：
Sun J;Zhou G;Zhang Y;Zhou T;Nie C;Zhu T;Chen S;Wang B;Yu Z;Wang H;Chen X;Hong L;Chen L;Wang W;Zheng S
本研究旨在探讨首次药物洗脱微球肝动脉化疗栓塞术(DEB-TACE；FD)与第二次及以上DEB-TACE(SHD)患者常见不良事件(AEs)的差异及影响AEs的因素。在这项队列研究中，共回顾了520例DEB-TACE记录，其中FD组284例，SHD组236例。收集疼痛、发热、呕吐和血压升高的发生率和/或严重程度。疼痛数值评分(NRS)、疼痛程度、体温、发热程度、发热持续天数FD组高于SHD组，而呕吐和血压升高两组差异无统计学意义。年龄≥65岁与FD组高热程度降低、呕吐可能性减少、疼痛和发热程度降低有关；两组男性呕吐机率降低，SHD组BP发生率增加；FD组糖尿病病史与疼痛程度减轻、发热程度减轻相关。结论：肝癌患者对SHD的耐受性好于FD，且年龄和男性与DEB-TACE术中常见AEs的发生率或严重程度相关。
This study aimed to investigate the difference of common adverse events (AEs) between patients experienced first drug-eluting beads transarterial chemoembolization (DEB-TACE; FD) and second or higher DEB-TACE (SHD), and the factors influencing AEs. Five hundred twenty DEB-TACE records were retrospectively reviewed in this cohort study, among which 284 and 236 records were in FD and SHD groups, respectively. The incidence and/or severity of pain, fever, vomiting, and increased blood pressure (BP) were collected. Pain numerical rating scale (NRS) score, pain severity, body temperature, fever severity, and fever lasting days were higher in FD group than in SHD group, while no difference of vomiting and increased BP between 2 groups were disclosed. Age ≥65 years was associated with decreased high fever and less possibility of vomiting in FD group, and lower pain and fever severity in SHD group; Male decreased the possibility of vomiting in both the groups, and reduced increased BP incidence in SHD group; diabetes history correlated with decreased pain degree and less fever in FD group. In conclusion, SHD was better tolerated compared with FD in liver cancer patients, and older age as well as male were correlated with less occurrence or severity of common AEs in DEB-TACE operation.