The Long-QT Syndrome
The Long-QT Syndrome
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DOI：
10.1161/hc0702.105125
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发表时间：
1992-05
期刊：
影响因子：
37.8
通讯作者：
A. Moss;Jennifer L. Robinson
中科院分区：
文献类型：
--
作者：
A. Moss;Jennifer L. Robinson
心脏是一个泵，受到电信号的刺激，每分钟跳动约 50 至 180 次，具体取决于个人的活动水平和情绪状态。心脏本身由数百万个细胞组成，这些细胞会产生重复的放电序列（在医学上称为去极化）和充电（复极化），从而产生每次心跳。心脏细胞的电活动是由钠、钾和钙离子进出细胞的同步运动产生的。 ### 长 QT 综合征 长 QT 综合征 (LQTS) 是一种心脏电活动紊乱，可导致昏厥（昏厥，也称为晕厥）或心源性猝死。它很少发生，是由遗传性疾病（LQTS 遗传性形式）或某些处方药（LQTS 获得性形式）引起的。 QT 是指心电图上心脏放电开始到电恢复之间的时间间隔（见图 1）。图 1 说明了如何在心电图上测量 QT 间期。心电图记录的一次心跳的电活动示意图。心室的放电（去极化）由 QRS 波群表示，T 波反映电恢复（复极）。 QT是从QRS波群开始到T波结束的时间间隔，正常个体一般小于0.44秒。在患有长 QT 综合征的受试者中，QT 通常长于 0.44 秒。心脏内的电恢复延迟可能与非常危险、快速和混乱的心律有关（这些异常心律的医学术语是……
The heart is a pump that is stimulated by electrical signals to beat between about 50 to 180 times per minute, depending upon the individual’s level of activity and emotional state. The heart itself is made up of millions of cells that generate repetitive sequences of electrical discharges (referred to in medicine as depolarization) and recharging (repolarization) that produce each heart beat. Electrical activity of the heart cells is produced by the synchronized movement of sodium, potassium, and calcium ions into and out of the cells. ### Long-QT Syndrome Long-QT Syndrome (LQTS) is a disorder of the electrical activity of the heart that can result in blackouts (fainting, also known as syncope) or sudden cardiac death. It occurs infrequently and is caused either by an inherited genetic condition (inherited form of LQTS) or by some prescription medications (acquired form of LQTS). QT refers to the interval on ECG between the beginning of the heart’s electrical discharge through its electrical recovery (see Figure 1). Figure 1 illustrates how the QT interval is measured on the ECG. Schematic diagram of the electrical activity of one heart beat recorded by an ECG. The electrical discharge (depolarization) of the ventricle is represented by the QRS complex, with the T wave reflecting electrical recovery (repolarization). The QT is the time interval from the beginning of the QRS complex to the end of the T wave, and is generally less than 0.44 seconds in normal individuals. In subjects with the long-QT syndrome, the QT is usually longer than 0.44 seconds. Delayed electrical recovery within the heart can be associated with very dangerous, rapid, and chaotic heart rhythms (medical terms for these abnormal heart rhythms are …