A new method to identify dynamic transduction properties of aortic baroreceptors.
A new method to identify dynamic transduction properties of aortic baroreceptors.
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一种识别主动脉压力感受器动态传导特性的新方法。
DOI：
10.1152/ajpheart.1990.258.3.h887
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Motoomi Nakamura
中科院分区：
文献类型：
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作者：
M. Sugimachi;Tsutomu Imaizumi;Kenji Sunagawa;Yoshitaka Hirooka;Koji Todaka;Akira Takeshita;Motoomi Nakamura
我们使用“白噪声技术”在 17 只 α-氯醛糖麻醉的兔子中确定了主动脉弓压力感受器的动态转导特征。我们记录主动脉压力和主动脉降压神经活动，同时通过快速、间歇性心室起搏（400 次/分钟）扰动压力。将神经活动和压力之间的互功率谱除以压力的功率谱得到传递函数。随着频率从 0.005 Hz 增加到 5 Hz，传递函数的增益增加了三倍，这表明压力感受器主要对压力的动态变化而不是静态变化做出反应。为了量化压力感受器转导的非线性特性，我们将测量的瞬时神经活动与线性预测的神经活动进行了比较。我们证明了主要的非线性可归因于“阈值”。整体压力感受器转导特性可以通过线性子系统的级联连接和随后具有阈值的非线性子系统来表示。白噪声技术使得识别非线性系统中的无偏线性特性成为可能，因此对于识别复杂的生物系统非常有用。
We identified, in 17 alpha-chloralose-anesthetized rabbits, the dynamic transduction characteristics of the aortic arch baroreceptors using a "white-noise technique." We recorded aortic pressure and aortic depressor nerve activity while perturbing pressure by rapid, intermittent ventricular pacing (400 beats/min). Dividing the cross-power spectrum between nerve activity and pressure by the power spectrum of pressure yielded the transfer function. The gain of the transfer function increased threefold as the frequency increased from 0.005 to 5 Hz, suggesting that the baroreceptors responded primarily to dynamic rather than to static changes in pressure. To quantify the nonlinear properties of baroreceptor transduction, we compared measured instantaneous nerve activity with that linearly predicted. We demonstrated that the major nonlinearity was attributable to "threshold". The overall baroreceptor transduction properties could be represented by a cascade connection of a linear subsystem followed by a nonlinear subsystem with threshold. The white-noise technique made it possible to identify the unbiased linear properties in a nonlinear system, and thus was very useful in identifying complex biological systems.