THE ROLES OF MACROPHAGE (M-PHI) AND PGE-2 IN POSTBURN IMMUNOSUPPRESSION
THE ROLES OF MACROPHAGE (M-PHI) AND PGE-2 IN POSTBURN IMMUNOSUPPRESSION
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DOI：
10.1016/0305-4179(92)90010-r
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发表时间：
1992-04-01
期刊：
影响因子：
2.7
通讯作者：
HSU, BX
中科院分区：
文献类型：
--
作者：
LIU, Y;HSU, BX
在 Con A 刺激脾淋巴细胞后，评估了全皮烧伤小鼠的烧伤后免疫抑制情况。 损伤后 24 小时内即可检测到免疫抑制，并在 3-7 天后达到最大程度。 在烧伤小鼠中，这种淋巴细胞增殖通过消耗贴壁细胞（M-PHI）而增强，而在正常小鼠中，通过注射来自烧伤小鼠的这些贴壁细胞，可以抑制这种淋巴细胞增殖。 这些结果表明 M-PHI 的存在具有抑制功能。 烧伤小鼠和正常小鼠的脾细胞自发胚细胞转化（SBT）没有发现差异，但去除M-PHI-s后，烧伤小鼠脾细胞的SBT显着升高。 因此，严重热损伤后，小鼠脾细胞中的 M-PHI 和淋巴细胞均被激活。
Postburn immunosuppression in mice with full skin thickness burns was assessed after Con A stimulation of splenic lymphocytes. The immunosuppression was detected within 24 h of injury and was maximal 3-7 days later. Such lymphocyte proliferation was enhanced by depletion of adherent cells (M-PHI) in burned mice and could be depressed in normal mice by injection of these adherent cells from burned mice. These results suggest the presence of M-PHI with a suppressor function. No difference in spontaneous blastogenic transformation (SBT) of spleen cells between the burned and normal mice was found, but after removal of the M-PHI-s the SBT of spleen cells of burned mice became significantly elevated. Hence both M-PHI and lymphocytes in mouse spleen cells were activated after severe thermal injury.