RISK-FACTORS FOR WHEEZING DURING INFANCY - A STUDY OF 5953 INFANTS
RISK-FACTORS FOR WHEEZING DURING INFANCY - A STUDY OF 5953 INFANTS
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DOI：
10.1111/j.1651-2227.1987.tb10555.x
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发表时间：
1987-09-01
期刊：
影响因子：
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通讯作者：
NYBOE, J
中科院分区：
文献类型：
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作者：
BISGAARD, H;DALGAARD, P;NYBOE, J
在5,953名儿童中研究了婴儿期喘息发生的危险因素。这项研究的数据来自于对1959年至1961年出生的儿童进行的一项大型前瞻性调查，这些儿童参加了为期一年的随访检查。如果在出生后第一年内至少观察到一次喘息症状，而不伴有肺炎、会厌炎或急性喉炎，则诊断为喘息。Logit分析用于评估环境和其他因素对婴儿喘息风险的因果影响。通过回归技术评估风险因素，需要将某些其他变量纳入回归模型。关于列入其他变量的一般规则已经制定并适用于上述数据。这项研究表明，喘息的风险受到许多因素的影响，特别是环境因素。不良的社会环境、母亲的吸烟和将婴儿放在日托所会增加喘息的风险。男孩比女孩更常发生喘鸣。早产儿比成年儿童更容易发生喘息。值得注意的是，4月至9月出生的孩子比10月至3月出生的孩子更容易患哮喘，但不会患支气管炎。
Risk factors for the development of wheezing during infancy were studied in 5,953 children. The data for the study were collected from a large prospective investigation of children born in 1959-61, who had attended a one-year follow-up examination. Wheezing was diagnosed when the symptom had been observed at least once during the first year of life, not in conjunction with pneumonia, epiglottitis or acute laryngitis. Logit analysis was used for the purpose of assessing the causal effect of environmental and other factors on the risk of wheezing among infants. The assessment of a risk factor by means of regression technique, requires certain other variables to be included in the regression model. A general rule concerning inclusion of other variables has been formulated and applied to the above data. The study demonstrated that the risk of wheezing was affected by a number of factors-particularly environmental. Poor social environment increases the risk of wheezing, as does the mother''s smoking, and placement of the baby in day-care. Boys experienced wheezing more often than girls. Premature infants are more liable to develop wheezing than mature children. Remarkably, children born in the period April through September develop wheezing, but not bronchitis, more often than children born in October through March.