PHARMACOLOGICAL EVIDENCE FOR THE INVOLVEMENT OF THE ENDOGENOUS OPIOID SYSTEM IN THE RESPONSE TO LOCAL INFLAMMATION IN THE RAT PAW
PHARMACOLOGICAL EVIDENCE FOR THE INVOLVEMENT OF THE ENDOGENOUS OPIOID SYSTEM IN THE RESPONSE TO LOCAL INFLAMMATION IN THE RAT PAW
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DOI：
10.1016/0304-3959(94)00090-2
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发表时间：
1995-01-01
期刊：
影响因子：
7.4
通讯作者：
PUIG, MM
中科院分区：
文献类型：
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作者：
PLANAS, ME;RODRIGUEZ, L;PUIG, MM
我们研究了内源性阿片系统（EOS）在大鼠足底下（s.p）注射生理盐水（SS）和卡拉胶（CA）诱导的炎症反应中的作用。腹腔注射纳洛酮是为了揭示外周炎症释放的内源性阿片类药物的作用。三组大鼠分别接受SS、CA或不注射（NI）三种不同的sp治疗。在基线条件下和治疗后3小时评估痛压阈值（PPT）、足部体积（水肿）和局部温度。观察各组灌胃药、纳洛酮和(+)-纳洛酮（0.1 mg/kg）的作用。SS和CA均引起明显的炎症反应，伴有痛觉过敏、水肿和局部高热。在试验前15分钟给予纳洛酮而不给予(+)-纳洛酮，各组水肿均明显增加(P
We have investigated the role of the endogenous opioid system (EOS) on the inflammatory response induced by subplantar (s.p.) injection of saline (SS) and carrageenan (CA) in the hindpaw of the rat. The administration of intraperitoneal (i.p.) naloxone was used in order to unmask the effects of endogenous opiates released during peripheral inflammation. Three groups of rats received one of the following s.p. treatments: SS, CA, or no injection (NI). Pain pressure threshold (PPT), paw volume (edema) and local temperature were evaluated in baseline conditions and 3 h after treatment. In each group, the effects of i.p. vehicle, naloxone and (+)-naloxone (0.1 mg/kg) were also investigated. Both SS and CA induced a significant inflammatory response with hyperalgesia, edema and local hyperthermia. The i.p. administration of naloxone but not that of (+)-naloxone 15 min prior to testing, significantly increased edema in all groups of treatment (P