Genetic and lifestyle predictors of ischemic stroke severity and outcome
Genetic and lifestyle predictors of ischemic stroke severity and outcome
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DOI：
10.1007/s10072-019-04006-y
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发表时间：
2019-12-01
影响因子：
3.3
通讯作者：
Simundic, Ana-Maria
中科院分区：
文献类型：
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作者：
Celap, Ivana;Gabaj, Nora Nikolac;Simundic, Ana-Maria
包括临床变量和血液标志物在内的不同模型已经被研究用于预测急性缺血性卒中的治疗过程和恢复。目的研究血脂水平、生活方式因素、止血（F5、F2、SERPINE1、F13A1和FGB）和致动脉粥样硬化（APOA5和ACE）基因变异与急性缺血性卒中（AIS）严重程度之间的关系。材料与方法本研究纳入250例AIS患者，检测其中F5、F2、SERPINE1、F13A1、FGB、APOA5和ACE基因型。在AIS发病24小时内测量总胆固醇（TC）、高密度胆固醇、低密度胆固醇和甘油三酯浓度。使用美国国立卫生研究院卒中量表/评分（NIHSS）对神经功能缺陷进行检查。结果apoa5基因型[TC + CC]在NIHSS评分>= 21的患者中更为常见（P=0.026）。单因素回归分析显示，甘油三酯（OR 0.55, 95% CI 0.34-0.91； P=0.019）、肥胖（OR 0.28, 95% CI 0.10-0.73； P=0.010）、年龄（OR 1.08, 95% CI 1.04-1.13； P=0.019）与糖尿病相关
BackgroundDifferent models that include clinical variables and blood markers have been investigated to predict acute ischemic stroke treatment course and recovery.AimThe aim of the study was to investigate associations between lipid levels, lifestyle factors, hemostatic (F5, F2, SERPINE1, F13A1, and FGB), and atherogenic (APOA5 and ACE) gene variants and acute ischemic stroke (AIS) severity.Materials and methodsThis study included 250 patients with AIS in which F5, F2, SERPINE1, F13A1, FGB, APOA5, and ACE genotypes were determined. Total cholesterol (TC), high-density cholesterol, low-density cholesterol, and triglycerides concentrations were measured within 24 h of the AIS onset. Examination of the neurological deficit was done using National Institutes of Health Stroke Scale/Score (NIHSS).ResultsAPOA5 genotype [TC + CC] was more frequent (P=0.026) in patients with the NIHSS score >= 21. Univariate regression analysis has shown that triglycerides (OR 0.55, 95% CI 0.34-0.91; P=0.019), obesity (0.28, 95% CI 0.10-0.73; P=0.010), age (OR 1.08, 95% CI 1.04-1.13; P