Experimental allergic encephalomyelitis. II. Retinal and other ocular manifestations.
Experimental allergic encephalomyelitis. II. Retinal and other ocular manifestations.
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实验性过敏性脑脊髓炎。
DOI：
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发表时间：
1981
影响因子：
4.4
通讯作者：
S. Hayreh
中科院分区：
文献类型：
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作者：
S. Hayreh
用6只成年恒河猴复制实验性变态反应性脑脊髓炎（EAE）。所有动物均发生急性EAE。所有患眼均发生视神经炎。在12只眼睛中的5只眼睛中观察到血管闭塞性视网膜病变。部分眼出现结膜炎和虹膜睫状体炎。现有的证据表明，视网膜病变是继发于视神经的变化，代表视网膜中央静脉阻塞的神经内压迫。组织学检查显示视网膜或视网膜血管周围无炎性浸润迹象。
Experimental allergic encephalomyelitis (EAE) was produced in 6 adult rhesus monkeys. All the animals developed acute EAE. Optic neuritis developed in all eyes. A vasculo-occlusive retinopathy was seen in five of the 12 eyes. Conjunctivitis and iridocyclitis were seen in some eyes. The available evidence indicates that the retinopathy is secondary to the optic nerve changes and represents central retinal vein occlusion by intraneural compression. Histopathologic studies revealed no evidence of inflammatory infiltration in the retina or around the retinal vessels.