A Catalytic Intermolecular Formal Ene Reaction between Ketone-Derived Silyl Enol Ethers and Alkynes
A Catalytic Intermolecular Formal Ene Reaction between Ketone-Derived Silyl Enol Ethers and Alkynes
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DOI：
10.1021/jacs.6b06847
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发表时间：
2016-09-28
影响因子：
15
通讯作者：
Pronin, Sergey V.
中科院分区：
文献类型：
--
作者：
Holmbo, Stephen D.;Godfrey, Nicole A.;Pronin, Sergey V.
本文报道了一种酮衍生的硅烯醇醚与末端炔之间的催化甲缩醛烯反应。这种转化能够独特地进行2-甲硅烷氧基-1，4-二烯的双分子组装，并可用于获得在α-位含有季碳的β，γ-不饱和酮
A catalytic formal ene reaction between ketone-derived silyl enol ethers and terminal alkynes is described. This transformation is uniquely capable of bimolecular assembly of 2-siloxy-1,4-dienes and can be used to access beta,gamma-unsaturated ketones containing quaternary carbons in the alpha-position