MR diffusion imaging of cerebral infarction in humans.
MR diffusion imaging of cerebral infarction in humans.
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发表时间：
1992-07
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通讯作者：
D. Chien;K. K. Kwong-K.;D. R. Gress;F. Buonanno;R. B. Buxton;B. R. Rosen
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作者：
D. Chien;K. K. Kwong-K.;D. R. Gress;F. Buonanno;R. B. Buxton;B. R. Rosen
目的通过磁共振扩散成像研究脑梗死患者水扩散的变化。方法采用表观扩散系数（ADC）绘制扩散图，显示15例患者脑组织局部水分迁移情况。将这些ADC图与常规t2加权图像进行比较。结果：即使梗死区域在t2加权图像上表现均匀，也可以检测到不同水扩散的不同亚区。结果还表明，相同年龄的脑卒中病变可以有非常不同的水扩散。在一组在多个时间点成像的患者中，观察到在急性事件发生后的最初几天内病变扩散系数增加的趋势。结论体内扩散系数的测量为更好地了解人类梗死演变过程中发生的生物物理变化提供了机会。
PURPOSE MR diffusion imaging was performed to investigate changes in water diffusion in patients with cerebral infarction. METHODS Diffusion maps of the apparent diffusion coefficient (ADC) were created to show local water mobility in the brain tissue in 15 patients. These ADC maps were compared with conventional T2-weighted images. RESULTS Distinct subregions with different water diffusions were detected, even when the infarcted area appeared homogeneous on a T2-weighted image. The results also show that stroke lesions of the same age can have very different water diffusions. A trend towards an increasing diffusion coefficient in a lesion during the first several days following an acute event was observed in a group of patients imaged at multiple timepoints. CONCLUSION The measurement of diffusion coefficients in vivo now offers an opportunity for greater understanding of the biophysical changes that occur during the evolution of infarction in humans.