Antihypertensive activity of peptides identified in the in vitro gastrointestinal digest of pork meat
Antihypertensive activity of peptides identified in the in vitro gastrointestinal digest of pork meat
复制标题
DOI：
10.1016/j.meatsci.2012.02.007
复制
发表时间：
2012-07-01
期刊：
影响因子：
7.1
通讯作者：
Arihara, Keizo
中科院分区：
文献类型：
--
作者：
Escudero, Elizabeth;Toldra, Fidel;Arihara, Keizo
本研究研究了从猪肉体外消化中鉴定的三种新多肽的体内降压活性。这些多肽分别为RPR、KAPVA和PTPVP，对自发性高血压大鼠灌胃给药后均显示出显著的降压活性。RPR是体内活性最强的多肽。据我们所知，这是首次报道了这三个来自NeBulin(RPR)和Titin(KAPVA和PTPVP)的多肽在体内的降压作用，从而证实了它们在体外的血管紧张素转换酶(ACE)抑制活性。这些发现表明，猪肉可能是生物活性成分的来源，可以用于功能性食品或营养食品。(C)2012爱思唯尔有限公司。保留所有权利。
This study investigated the in vivo antihypertensive activity of three novel peptides identified in the in vitro digest of pork meat. These peptides were RPR, KAPVA and PTPVP and all of them showed significant antihypertensive activity after oral administration to spontaneously hypertensive rats. RPR being the peptide with the greatest in vivo activity. To our knowledge, this is the first report showing the in vivo antihypertensive action of the three peptides from nebulin (RPR) and titin (KAPVA and PTPVP), thus confirming their reported in vitro angiotensin I-converting enzyme (ACE) inhibitory activity. These findings suggest that pork meat could constitute a source of bioactive constituents that could be utilized in functional foods or nutraceuticals. (c) 2012 Elsevier Ltd. All rights reserved.