Light-Intensity Physical Activities and Mortality in the United States General Population and CKD Subpopulation
Light-Intensity Physical Activities and Mortality in the United States General Population and CKD Subpopulation
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DOI：
10.2215/cjn.08410814
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发表时间：
2015-07-01
影响因子：
9.8
通讯作者：
Greene, Tom
中科院分区：
文献类型：
--
作者：
Beddhu, Srinivasan;Wei, Guo;Greene, Tom
背景与目的在一般人群中，久坐行为与死亡率增加有关。是否用低强度或轻强度的活动取代久坐行为对一般人群或CKD人群的生存有好处尚不清楚。设计、环境、参与者和测量对2003-2004年全国健康和营养调查进行了观察性分析，研究了低强度和低强度活动与死亡率之间的关系。根据加速度计记录的计数/分钟/久坐活动的持续时间（= 2020/分钟）被定义并标准化为60分钟。在整个队列和CKD亚组的多变量Cox回归模型中，研究了久坐时间减少2分钟/小时与低、轻或中/剧烈活动时间增加2分钟/小时（权衡）同时控制其他两种活动时间的死亡率关联。结果在纳入的3626名参与者中，383名患有CKD。整个队列的平均久坐时间为34.4 +/- 7.9分钟/小时，CKD亚组为40.8 +/- 6.8分钟/小时。在整个队列或CKD亚组中，久坐时间与低活动时间的权衡与死亡率无关。在整个队列（风险比，0.67；95%可信区间，0.48至0.93）和CKD亚组（风险比，0.59；95%可信区间，0.35至0.98）中，久坐时间与轻度活动时间的权衡与较低的死亡风险相关。在整个队列和CKD亚组中，久坐时间与中度/剧烈活动时间的权衡风险不显著降低。结论CKD患者近三分之二的时间久坐不动。用增加轻度活动时间来取代久坐的干预措施可能会带来生存益处。
Background and objectives Sedentary behavior is associated with increased mortality in the general population. Whether replacing sedentary behavior with low- or light-intensity activities confers a survival benefit in the general or CKD populations is unknown.Design, setting, participants, & measurements This observational analysis of the 2003-2004 National Health and Nutrition Examination Survey examined the associations of low- and light-intensity activities with mortality. On the basis of the number of counts/min recorded by an accelerometer/durations of sedentary (= 2020/min) activity were defined and normalized to 60 minutes. The mortality associations of 2 min/hr less sedentary duration in conjunction with 2 min/hr more (tradeoff) spent in one of the low, light, or moderate/vigorous activity durations while controlling for the other two activity durations were examined in multivariable Cox regression models in the entire cohort and in the CKD subgroup.Results Of the 3626 participants included, 383 had CKD. The mean sedentary duration was 34.4 +/- 7.9 min/hr in the entire cohort and 40.8 +/- 6.8 in the CKD subgroup. Tradeoff of sedentary duration with low activity duration was not associated with mortality in the entire cohort or the CKD subgroup. Tradeoff of sedentary duration with light activity duration was associated with a lower hazard of death in the entire cohort (hazard ratio, 0.67; 95% confidence interval, 0.48 to 0.93) and CKD subgroup (hazard ratio, 0.59; 95% confidence interval, 0.35 to 0.98). Tradeoff of sedentary duration with moderate/vigorous activity duration had a nonsignificant lower hazard in the entire cohort and CKD subgroup.Conclusions Patients with CKD are sedentary nearly two thirds of the time. Interventions that replace sedentary duration with an increase in light activity duration might confer a survival benefit.