State-dependent signaling by Cav1.2 regulates hair follicle stem cell function.
State-dependent signaling by Cav1.2 regulates hair follicle stem cell function.
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DOI：
10.1101/gad.216556.113
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发表时间：
2013-06
影响因子：
10.5
通讯作者：
Gozde Yucel;Banu Altindag;N. Gomez-Ospina;Anshul Rana;Georgia Panagiotakos;M. F. Lara;R. Dolmetsch;A. Oro
中科院分区：
文献类型：
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作者：
Gozde Yucel;Banu Altindag;N. Gomez-Ospina;Anshul Rana;Georgia Panagiotakos;M. F. Lara;R. Dolmetsch;A. Oro
The signals regulating stem cell activation during tissue regeneration remain poorly understood. We investigated the baldness associated with mutations in the voltage-gated calcium channel (VGCC) Cav1.2 underlying Timothy syndrome (TS). While hair follicle stem cells express Cav1.2, they lack detectable voltage-dependent calcium currents. Cav1.2(TS) acts in a dominant-negative manner to markedly delay anagen, while L-type channel blockers act through Cav1.2 to induce anagen and overcome the TS phenotype. Cav1.2 regulates production of the bulge-derived BMP inhibitor follistatin-like1 (Fstl1), derepressing stem cell quiescence. Our findings show how channels act in nonexcitable tissues to regulate stem cells and may lead to novel therapeutics for tissue regeneration.
