FK506 potentiates steroid-induced T-cell apoptosis
FK506 potentiates steroid-induced T-cell apoptosis
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DOI：
10.1097/00007890-199711150-00022
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发表时间：
1997-11-15
期刊：
影响因子：
6.2
通讯作者：
Nagataki, S
中科院分区：
文献类型：
--
作者：
Migita, K;Eguchi, K;Nagataki, S
Background. FK506 and glucocorticoids are used for allograft rejection, graft-versus-host disease, and autoimmune diseases.Materials. me investigated the combined effect of FK506 and glucocorticoids on T-cell apoptosis.Results. Dexamethasone injection in mice reduced the number of CD4(+)CD8(+) thymocytes by increasing DNA fragmentation. Pretreatment with FK506 significantly augmented thymocyte DNA fragmentation induced by dexamethasone injection. Increased thymic apoptosis resulted in the disappearance of CD4(+)CD8(+) thymocytes after FK506/dexamethasone injection. In addition to thymocytes, mature human peripheral blood T cells undergo apoptosis by exposure to dexamethasone in vitro. FK506 synergistically enhanced dexamethasone-mediated apoptosis of human peripheral blood T cells.Conclusions. Thus, our results showed that FK506 enhanced dexamethasone-induced apoptosis of T cells in vivo and in vitro. This interaction may enhance the therapeutic immunosuppression achieved by these two drugs.
