Relationships Between HIV Disease History and Blood HIV-1 DNA Load in Perinatally Infected Adolescents and Young Adults: The ANRS-EP38-IMMIP Study
Relationships Between HIV Disease History and Blood HIV-1 DNA Load in Perinatally Infected Adolescents and Young Adults: The ANRS-EP38-IMMIP Study
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DOI：
10.1093/infdis/jis233
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发表时间：
2012-05-15
影响因子：
6.4
通讯作者：
Buseyne, Florence
中科院分区：
文献类型：
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作者：
Avettand-Fenoel, Veronique;Blanche, Stephane;Buseyne, Florence
我们的目的是研究终身人类免疫缺陷病毒（HIV）病史对围产期感染患者成年后当前免疫和病毒学状况的影响。我们评估了血细胞相关HIV DNA负荷作为细胞相关HIV库的指标和疾病进展的独立预测因子。anrs - ep38 - imip研究纳入了93例年龄在15-24岁的围产期感染HIV的患者。实时聚合酶链反应定量HIV DNA载量。85%的患者正在接受高效抗逆转录病毒治疗（HAART），其中75%的患者血浆中检测不到HIV RNA。中位HIV DNA载量为2.84（四分位数范围，2.51-3.16）log（10）拷贝/ 10(6)个外周血单个核细胞。在病毒抑制的患者中，HIV DNA载量与过去5年累积HIV RNA病毒血症独立相关。在复制活跃的患者中，HIV DNA载量与CD4细胞计数呈负相关，而在无法检测到HIV RNA的患者中则无相关。在成功治疗的围产期感染青年中，持续的病毒抑制与低HIV DNA负荷有关。当前HIV DNA载量和CD4细胞计数之间不存在关联，这表明儿童感染的独特生理特征在青春期后仍然存在。
Our aim was to study the impact of lifelong human immunodeficiency virus (HIV) disease history on the current immune and virological status of perinatally infected patients reaching adulthood. We evaluated blood cell-associated HIV DNA load as an indicator of cell-associated HIV reservoirs and an independent predictor of disease progression.The ANRS-EP38-IMMIP Study included 93 patients aged 15-24 years who were infected with HIV during the perinatal period. HIV DNA load was quantified by real-time polymerase chain reaction.Eighty-five percent of patients were receiving highly active antiretroviral therapy (HAART), and HIV RNA was undetectable in the plasma of 75% of these patients. The median HIV DNA load was 2.84 (interquartile range, 2.51-3.16) log(10) copies per 10(6) peripheral blood mononuclear cells. In patients with viral suppression, HIV DNA load was independently associated with cumulative HIV RNA viremia over the last 5 years. HIV DNA load was negatively correlated with CD4 cell count in patients with active replication but not in those with undetectable HIV RNA.In perinatally infected youths who are successfully treated, sustained viral suppression is associated with a low HIV DNA load. The absence of association between current HIV DNA load and CD4 cell counts suggests that the unique physiological characteristics of pediatric infection persist after adolescence.NCT01055873.