A follow-up study of colonic epithelial proliferation as a biomarker ina Native-American family with hereditary nonpolyposis colon cancer.
A follow-up study of colonic epithelial proliferation as a biomarker ina Native-American family with hereditary nonpolyposis colon cancer.
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结肠上皮增殖作为遗传性非息肉病性结肠癌美洲原住民家庭生物标志物的后续研究。
DOI：
10.1093/jnci/83.13.951
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Lynch,J
中科院分区：
文献类型：
--
作者：
Lynch,PM;Wargovich,MJ;Lynch,HT;Palmer,C;Lanspa,S;Drouhard,T;Lynch,J
对一个患有遗传性非息肉病结肠癌的美洲原住民家庭成员进行了一项为期7年的结肠粘膜增殖标记物的随访研究。在这个具有生物学意义的7年时间框架内，用于标记指数的氚胸苷放射自显影试验的重复性被确立。氚胸腺嘧啶核苷与一种新的技术--溴脱氧尿苷免疫过氧化物酶染色--有很好的相关性。不能归因于标准结肠制剂的混淆效应。平均而言，上皮细胞增殖的基线值和随访值均在可接受的正常范围内。在结肠癌患者和他们的高危后代中存在基本正常的标记指数，这表明饮食因素在抑制增殖方面可能具有显著作用。这些因素可能解释了美国西南部美洲原住民人口患结肠癌的低风险。[美国国家癌症研究所83：951-954,1991]
A 7–year follow–up study of colonic mucosa proliferation markers was conducted on members of a Native–American family with hereditary non–polyposis colon cancer. Reproducibility of a tritiated thymidine autoradiography assay for labeling indexes during this 7–year biologically significant time frame was established. A good correlation between tritiated thymidine and a newer technique, bromodeoxyuridine immunoperoxidase staining, was seen. No confounding effect could be attributed to standard colon preparation. On average, both baseline and follow–up values for epithelial proliferation were within the accepted normalrange. The presence of essentially normal labeling indexes among colon cancer patients and their high–risk offspring suggests the possibility of the significant effect of dietary factors in reducing proliferation. Such factors may account for the low risk of colon cancer that characterzies the Native–American population in the American Southwest. [J Natl Cancer Inst 83: 951–954, 1991]