Influence of aortic impedance on the development of pressure-overload left ventricular hypertrophy in rats
Influence of aortic impedance on the development of pressure-overload left ventricular hypertrophy in rats
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DOI：
10.1161/01.cir.94.12.3362
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发表时间：
1996-12-15
期刊：
影响因子：
37.8
通讯作者：
Matsuzaki, M
中科院分区：
文献类型：
--
作者：
Kobayashi, S;Yano, M;Matsuzaki, M
背景 主动脉输入阻抗代表左心室后负荷，被认为是压力超负荷性左心室 (LV) 肥厚发展的主要决定因素。 方法和结果 为了测试主动脉输入阻抗的持续变化是否可能影响左心室肥厚的发展模式，在 4 周内对升主动脉 (G1，n=13) 或肾上腹主动脉 (G2，n=12) 进行缩窄。 6周大的Wistar大鼠。尽管 G1 和 G2 中左室峰值压力和总系统阻力增加类似，但左室压力峰值时间缩短了 24%（P
Background Aortic input impedance, which represents LV afterload, is considered to be a major determinant for the development of pressure-overload left ventricular (LV) hypertrophy.Methods and Results To test whether the sustained change in aortic input impedance might affect the mode of development of LV hypertrophy, coarctation of either the ascending aorta (G1, n=13) or suprarenal abdominal aorta (G2, n=12) was performed over 4 weeks in 6-week-old Wistar rats. Although peak LV pressure and total systemic resistance were increased similarly in G1 and G2, time to peak LV pressure was decreased by 24% (P