Long-term adverse effects of hematopoietic stem cell transplantation on dental development in children
Long-term adverse effects of hematopoietic stem cell transplantation on dental development in children
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DOI：
10.1007/s00520-008-0567-1
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发表时间：
2009-09-01
影响因子：
3.1
通讯作者：
Gortzak, R. A. Th.
中科院分区：
文献类型：
--
作者：
Voskuilen, I. G. M. van der Pas-van;Veerkamp, J. S. J.;Gortzak, R. A. Th.
目的-本研究的目的是评估晚期影响的细胞毒性治疗与造血干细胞移植（HCT）对儿童cancer.Materials和方法的幸存者的牙齿发育40儿童谁接受同种异体HCT的各种血液恶性肿瘤移植后至少2年进行了评估。我们获得了有关口腔症状的信息，暴露了全景X线片（PRG），并进行了口腔检查。对PRG的发育不全和根和/或冠异常进行评分。计算根冠比，并使用Demirjian的方法进行牙龄评估。主要结果研究组显示，与正常数据相比，上颌骨和下颌骨中的第一和第二前磨牙以及下颌骨中的第二磨牙的牙齿发育不全的患病率显著较高（所有p值
Purpose The purpose of this study was to assess late effects of cytotoxic therapy with hematopoietic stem cell transplantation (HCT) on dental development in survivors of childhood cancer.Materials and methods Forty children who underwent allogeneic HCT for a variety of hematological malignancies were evaluated at a minimum of 2 years after transplantation. We obtained information on oral symptoms, exposed panoramic radiographs (PRG), and performed an oral examination. PRGs were scored for agenesis and root and/or crown abnormalities. The root-crown ratio was calculated, and dental age was assessed using Demirjian's method.Main results The studied group showed a significantly higher prevalence of tooth agenesis compared to normative data for first and second premolars in both the maxilla and mandible, as well as the second molars in the mandible (all p values