Synthesis of CF3-Substituted Sulfoximines from Sulfonimidoyl Fluorides
Synthesis of CF3-Substituted Sulfoximines from Sulfonimidoyl Fluorides
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DOI：
10.1021/ol103030w
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发表时间：
2011-02-18
期刊：
影响因子：
5.2
通讯作者：
Bolm, Carsten
中科院分区：
文献类型：
--
作者：
Kowalczyk, Rafal;Edmunds, Andrew J. F.;Bolm, Carsten
通过用Ruppert-Prakash试剂（TMSCF 3）和四丁基氟化铵（TBAF）的组合处理磺酰亚胺氟化物，制备了N-保护的三氟甲基取代的亚砜亚胺。按照两种合成路线获得起始物料，并对每个反应序列的底物范围进行评价。因此，以中等至良好的产率获得了多种芳基取代的产物。
N-Protected trifluoromethyl-substituted sulfoximines have been prepared by treatment of sulfonimidoyl fluorides with a combination of the Ruppert-Prakash reagent (TMSCF3) and tetrabutyl ammonium fluoride (TBAF). The starting materials were accessed following two synthetic routes, and for each reaction sequence the substrate scope was evaluated. Accordingly, a wide variety of aryl-substituted products were obtained in moderate to good yield.