Synthesis of quinazoin-4-ones through an acid ion exchange resin mediated cascade reaction.
Synthesis of quinazoin-4-ones through an acid ion exchange resin mediated cascade reaction.
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DOI：
10.1039/d0ob00881h
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发表时间：
2020-05
影响因子：
3.2
通讯作者：
Huiyong Yang;Jun Xu;Yilan Zhang;Lei He;Pengfei Zhang;Wanmei Li
中科院分区：
文献类型：
--
作者：
Huiyong Yang;Jun Xu;Yilan Zhang;Lei He;Pengfei Zhang;Wanmei Li
本文报道了N-（2-（4，5-二氢恶唑-2-基）苯基）苯甲酰胺在酸性离子交换树脂存在下的一个有趣的级联反应。在该反应中，一系列带有各种取代基的底物是良好相容的。本工作为喹唑啉-4-酮的高收率合成提供了一种绿色、原子经济的新途径。
An interesting cascade reaction of N-(2-(4,5-dihydrooxazol-2-yl)phenyl)benzamide in the presence of an acid ion exchange resin is described. In this reaction, a range of substrates bearing various substituent groups are well compatible. This work provides a green and atom-economical alternative approach for the synthesis of quinazolin-4-ones in good yields.