A stereocontrolled synthesis of δ-trans-tocotrienoloic acid
A stereocontrolled synthesis of δ-trans-tocotrienoloic acid
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DOI：
10.1021/ol051849t
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发表时间：
2005-09-15
期刊：
影响因子：
5.2
通讯作者：
Hecht, SM
中科院分区：
文献类型：
--
作者：
Maloney, DJ;Hecht, SM
描述了天然存在的聚合酶β抑制剂δ-反式生育三烯酸（2）的一致立体选择性全合成。合成的关键步骤是酸催化的环化脱水反应。此外，本报告纠正了先前报告的结构分配，定义了2的绝对立体化学，并定义了聚合酶β抑制的关键结构要求。
A consise stereoselective total synthesis of a naturally occurring polymerase beta inhibitor, delta-trans-tocotrienoloic acid (2), is described. The key step in the synthesis is an acid-catalyzed cyclodehydration reaction. Additionally, this report corrects a previously reported structural assignment, defines the absolute stereochemistry of 2, and defines key structural requirements for polymerase beta inhibition.