Sjögren's syndrome: a community-based study of prevalence and impact.
Sjögren's syndrome: a community-based study of prevalence and impact.
复制标题
干燥综合征：基于社区的患病率和影响研究。
DOI：
10.1093/rheumatology/37.10.1069
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
A. Silman
中科院分区：
文献类型：
--
作者：
E. Thomas;E. Hay;A. Hajeer;A. Silman
目标
使用欧洲共同体 (EC) 分类标准 Vitali 等人。 Arthritis Rheum 1993;36:340 7，我们报告了一般人群中干燥综合征 (SS) 的患病率估计值，并提供了第一个人口数据来评估该综合征的影响。
方法
对从人口登记册中随机选择的 1000 名 18-75 岁成年人进行了一项基于人口的横断面调查。最初邮寄阶段的回复者被邀请接受采访。访谈衡量的五个标准是：（1）报告主观口腔症状持续> 3个月； (2) 报告主观眼部症状持续>3个月； (3) Schirmer-I试验； (4)未受刺激的唾液流动； (5)自身抗体[Ro(SS-A)、La(SS-B)、类风湿因子(RF)、抗核抗体(ANA)]。如果这五个标准中至少有四个为阳性，则诊断为 SS。受访者在访谈后完成 MOS 简式 36 (SF-36)、一般健康问卷 (GHQ) 和健康与疲劳问卷 (HFQ)，并对诊断为 SS 和未诊断为 SS 的患者进行分数比较。
结果
共有 341 名受试者完成了邮寄问卷和家访。可以对 13 名受试者进行 SS 诊断。在调整由于无应答而可能存在的偏差后，我们对研究人群中 SS 患病率的最佳估计为每 1000 名受试者 33 例 (95% CI 22-44)。该疾病的患病率在女性（38 岁；95% CI 27-52）和 55 岁以上受试者（46 岁；95% CI 34-61）中较高。那些被诊断为阳性的受试者比那些没有诊断的受试者在 SF-36 的八个维度中的每一个维度都受到更严重的损害，并且还遭受更高程度的抑郁和疲劳。
结论
SS 影响大约 3-4% 的成年人，并且在一般人群中似乎与受试者健康和福祉的临床显着损害相关。
OBJECTIVE
Using the European Community (EC) criteria for classification Vitali et al. Arthritis Rheum 1993;36:340 7, we report the prevalence estimates of Sjogren's syndrome (SS) from a general population and present the first population data to assess the impact of the syndrome.
METHODS
A cross-sectional population-based survey performed on 1000 adults, aged 18-75 yr, randomly selected from a population register. Responders to the initial postal phase were invited for an interview. The five criteria measured at interview were: (1) the reporting of subjective oral symptoms lasting for > 3 months; (2) the reporting of subjective ocular symptoms lasting for >3 months; (3) Schirmer-I test; (4) unstimulated salivary flow; (5) autoantibodies [Ro (SS-A), La (SS-B), rheumatoid factor (RF), antinuclear antibodies (ANA)]. SS was diagnosed if at least four of these five criteria were positive. The MOS Short-form 36 (SF-36), General Health Questionnaire (GHQ) and the Health and Fatigue Questionnaire (HFQ) were completed by subjects after the interview, and scores were compared between those with and without a diagnosis of SS.
RESULTS
A total of 341 subjects completed both the postal questionnaire and home visit. A diagnosis of SS could be given to 13 subjects. After adjusting for the presence of possible bias due to non-response, our best estimate of the prevalence of SS in the study population was 33 per 1000 subjects (95% CI 22 44). The prevalence of the disorder was higher in females (38; 95% CI 27-52) and for those subjects aged > or = 55 yr (46; 95% CI 34-61). Those subjects diagnosed positively were more impaired for each of the eight dimensions of the SF-36 than those without a diagnosis, and also suffered from higher levels of depression and fatigue.
CONCLUSIONS
SS affects approximately 3-4% of adults and in the general population appears to be associated with a clinically significant impairment of a subject's health and well-being.