Applications of Simple Nanoparticle Zeolitic Imidazolate Framework-8 in Bio-medicine
Applications of Simple Nanoparticle Zeolitic Imidazolate Framework-8 in Bio-medicine
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DOI：
10.21127/yaoyimr20190008
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Zhang Zhaokun;Yan Xu;Kunfeng Zhao;Ying Zhang;C. Weijia;Li Xiaodi;Yanxia Meng;Yang Dicheng;Ping Wang;Jun Zhu
中科院分区：
文献类型：
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作者：
Zhang Zhaokun;Yan Xu;Kunfeng Zhao;Ying Zhang;C. Weijia;Li Xiaodi;Yanxia Meng;Yang Dicheng;Ping Wang;Jun Zhu
沸石咪唑骨架-8（ZIF-8）是一类典型的金属有机骨架（MOF），是一种新兴的由锌金属离子和有机键桥联的多孔配位聚合物。咪唑骨架-8分子筛由于其固有的多孔性、独特的pH敏感性以及优越的上级载药效率，在生物医药领域得到了广泛的关注和应用。在本文中，我们简要讨论了ZIF-8中各种药物的有效递送和控制释放，例如功能蛋白质、亲水性和疏水性药物。了解各种药物的载药过程对于开发新的药物释放系统具有重要意义。此外，我们还探索了ZIF与不同材料的合作机制。化学疗法、光动力学疗法、光热疗法和医学影像学的联合应用在纳米医学领域已经取得了显著的成就。
Zeolitic Imidazolate Framework-8 (ZIF-8) is a type of typical metal organic framework (MOF), which is an emerging porous coordination polymers that is bridged by zinc metal ions and organic linkages. Due to its intrinsic porous characteristics, unique pH sensitivity as well as superior drug loading efficiency, zeolitic imidazolate framework-8 has attracted extensive attention and received a wide range of applications in the field of biomedicine. In this review, we briefly discuss the effective delivery and controlled release of various drugs in ZIF-8, such as functional proteins, hydrophilic and hydrophobic drugs. Understanding the processes of various drugs loading is important for developing new drug delivery systems. In addition, we also explored the cooperation mechanism between ZIF and different materials. The combination of chemotherapy, photodynamic therapy, photothermal therapy and medical imaging have been applied in the field of nanomedicine and have made emarkable achievements.