Human Serum Complement C3 and Factor H in the Syndrome of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count
Human Serum Complement C3 and Factor H in the Syndrome of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count
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DOI：
10.1111/j.1600-0897.2009.00731.x
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发表时间：
2009-10-01
影响因子：
3.6
通讯作者：
Ozener, Cetin
中科院分区：
文献类型：
--
作者：
Ari, Elif;Yilmaz, Yusuf;Ozener, Cetin
溶血、肝酶升高和低血小板计数综合征（HELLP综合征）是孕妇严重先兆子痫的一种危及生命的变异。补体系统可能在这种情况的发病机制中起作用。我们试图确定HELLP综合征的血清补体3（C3）水平及其调节蛋白补体因子H（FH）。（平均年龄：27.8 ± 6.2岁），21例无HELLP综合征的先兆子痫患者（平均年龄：27.5 ± 6.8岁）和24名血压正常的健康孕妇（平均年龄：26.1 ± 4.4岁）被纳入本研究。C3和FH的血清浓度测定在所有participant.ResultsC3和FH的浓度没有显着差异的研究组之间。在HELLP综合征患者中，FH水平与血小板计数呈正相关。结论这些研究结果并不支持补体激活在HELLP综合征中的主要作用。在HELLP患者中，较低水平的FH与血小板计数减少相关。
ProblemHemolysis, elevated liver enzymes, and low platelet count syndrome (HELLP syndrome) is a life-threatening variant of severe pre-eclampsia in pregnant women. The complement system may play a role in the pathogenesis of this condition. We sought to determine serum complement 3 (C3) levels and its regulatory protein complement factor H (FH) in the HELLP syndrome.Method of studyTwenty-two pre-eclamptic patients with HELLP syndrome (mean age: 27.8 +/- 6.2 years), 21 pre-eclamptic patients without HELLP syndrome (mean age: 27.5 +/- 6.8 years) and 24 normotensive, healthy pregnant women (mean age: 26.1 +/- 4.4 years) were included in this study. Serum concentrations of C3 and FH were measured in all participants.ResultsConcentrations of C3 and FH did not differ significantly between the study groups. In patients with the HELLP syndrome, FH levels were positively associated with platelet count.ConclusionThese findings did not support a major role of complement activation in the HELLP syndrome. In patients with HELLP, lower levels of FH are correlated with a reduced platelet count.