Cigarette smoking and risk of coronary heart disease incidence among middle-aged Japanese men and women: the JPHC Study Cohort I
Cigarette smoking and risk of coronary heart disease incidence among middle-aged Japanese men and women: the JPHC Study Cohort I
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DOI：
10.1097/01.hjr.0000194417.16638.3d
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发表时间：
2006-04-01
影响因子：
--
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
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作者：
Baba, Shunroku;Iso, Hiroyasu;Tsugane, Shoichiro
在亚洲，吸烟对冠心病（CHD）风险影响的性别特异性程度的数据很少。设计和方法一项基于人群的前瞻性队列研究，包括1990年至2000年年龄在40-59岁之间的19782名男性和21500名女性。结果1992年和2001年共确诊冠心病260例，其中心肌梗死174例。妇女的人数分别为66人和43人。在调整心血管危险因素、几种生活方式因素和公共卫生中心后，目前吸烟者与从不吸烟者的多变量相对风险[95%置信区间（CI）]为2.85（1.98，4.12），总CHD和MI为3.64（2.27，5.83）。女性的这些风险分别为3.07（1.48，6.40）和2.90（1.18，7.18）。在男性中，观察到吸烟数量与MI风险之间存在剂量依赖关系。CHD的人群归因风险百分比（95%CI）男性为46%（34，55），女性为9%（0，18）。戒烟，但是，导致冠心病的风险迅速下降，在2 years.Conclusion吸烟增加冠心病的风险显着在两种性别的中年日本人，具有很大的公共卫生意义，特别是在男性。戒烟将对降低风险产生直接影响。
Background Few data have been available on the sex-specific magnitude of the smoking effect on the risk of coronary heart disease (CHD) in Asia.Design and methods A population-based prospective cohort study of 19 782 men and 21 500 women aged 40-59 years between 1990-1992 and 2001 was conducted to examine the relationship between smoking status and the risk of CHD.Results A total of 260 incidences of CHD were confirmed among men, including 174 myocardial infarctions (MI). The numbers among women were 66 and 43, respectively. The multivariate relative risk [95% confidence interval (CI)] for current smokers versus never-smokers in men after adjustment for cardiovascular risk factors, several life style factors and public health centre was 2.85 (1.98, 4.12) for total CHD and 3.64 (2.27, 5.83) for MI. These respective risks in women were 3.07 (1.48, 6.40) and 2.90 (1.18, 7.18). Among men, a dose-dependent relationship was observed between the number of cigarettes and the risk of MI. The population-attributable risk per cent (95% CI) of CHD was 46% (34, 55) in men and 9% (0, 18) in women. Smoking cessation, however, led to a rapid decline in the CHD risk within 2 years.Conclusion Smoking raises the risk of CHD significantly in both sexes of middle-aged Japanese, with large public health significance especially in men. Smoking cessation would have an immediate effect on risk reduction.