Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques
Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques
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DOI：
10.1126/science.1140462
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发表时间：
2007-04-13
期刊：
影响因子：
56.9
通讯作者：
Bustamante, Carlos D.
中科院分区：
文献类型：
--
作者：
Hernandez, Ryan D.;Hubisz, Melissa J.;Bustamante, Carlos D.
为了了解恒河猴（Macaca mulatta）的人口统计学历史，并记录基因组中连锁不平衡（LD）的程度，我们对9只中国和38只圈养出生的印度恒河猴的5个DNA元件区域进行了部分重测序。对发现的1467个单核苷酸多态性的群体遗传分析表明，这两个群体在大约162，000年前分离，中国人口从那时起增加了两倍，印度人口最终减少了四倍。使用合并模拟，我们证实了这些推断的人口统计学事件解释了中国猕猴种群（10个月时r（2）约为0.15）比印度猕猴种群（10个月时r（2）约为0.52）LD衰减快得多。
To understand the demographic history of rhesus macaques ( Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximate to 0.15 at 10 kilobases) versus Indian (r(2) approximate to 0.52 at 10 kilobases) macaque populations.