THE DEVELOPMENT OF LARGE IMMATURE MONONUCLEAR CELLS IN MIXED LEUKOCYTE CULTURES.
THE DEVELOPMENT OF LARGE IMMATURE MONONUCLEAR CELLS IN MIXED LEUKOCYTE CULTURES.
复制标题
混合白细胞培养物中大型未成熟单核细胞的发育。
作者：
Barbara Bain;M. Vas;L. Lowenstein
1.当来自两个正常的、不相关的受试者的白细胞混合在一起并培养时，其中一些转化为大的嗜碱性细胞，可以合成DNA并进行有丝分裂。
2.这种变化的刺激是两组白细胞的存在。外来红细胞、血浆或血小板无影响。
3.对来自同卵和异卵双胞胎的白细胞混合物的研究表明，这种反应可能与两个受试者之间的遗传差异有关。
4.提示白细胞混合物中的反应可能与同种移植免疫有关。
1. When leukocytes from two normal, unrelated subjects are mixed together and cultured, some of them transform into large basophilic cells that can synthesize DNA and undergo mitosis.
2. The stimulus for this change is the presence of two sets of leukocytes. Foreign erythrocytes, plasma or platelets have no effect.
3. Studies with mixtures of leukocytes from pairs of identical and nonidentical twins indicate that the reaction may be related to genetic differences between the two subjects.
4. It is suggested that the reaction in leukocyte mixtures may be related to homograft immunity.