Acarbose treatment and the risk of cardiovascular disease in type 2 diabetic patients: a nationwide seven-year follow-up study.
Acarbose treatment and the risk of cardiovascular disease in type 2 diabetic patients: a nationwide seven-year follow-up study.
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DOI：
10.1155/2014/812628
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发表时间：
2014
影响因子：
4.3
通讯作者：
Sheu WH
中科院分区：
文献类型：
--
作者：
Chen JM;Chang CW;Lin YC;Horng JT;Sheu WH
目标。通过使用全国保险索赔数据集，调查阿卡波糖治疗2型糖尿病患者心血管疾病(CVD)的潜在益处。研究设计与方法。在一项全国性的队列研究中，在644,792名新诊断的无心血管疾病的2型糖尿病患者中，109,139人(16.9%)接受了阿卡波糖治疗，对其心血管风险进行了分析。对那些接受阿卡波糖治疗的CVD患者也进行了分析。结果。在7年的随访中，5081名患者(4.7%)发生了心血管疾病。粗危害比(HR)和调整后HR分别为0.66和0.99。使用阿卡波糖12个月、12-24个月和24个月时，心血管疾病的调整HR分别为1.19、0.70和0.38。阿卡波糖累积剂量为54,750 mg、54,751~109,500 mg和109,500 mg时，调整后HR分别为1.14、0.64和0.41。结论。在没有预先存在心血管疾病的2型糖尿病患者中，阿卡波糖治疗显示，在最初的12个月中，心血管疾病的发病率短暂增加，随后在长期使用阿卡波糖的患者中心血管疾病的发生率显著减少。在第一次CVD事件后，持续使用阿卡波糖在前12个月内显示出中性效果。潜在的机制需要进一步调查。
Objective. To investigate the potential benefits of acarbose treatment on cardiovascular disease (CVD) in patients with type 2 diabetes by using nationwide insurance claim dataset. Research Design and Methods. Among 644,792 newly diagnosed type 2 diabetic patients without preexisting CVD in a nationwide cohort study, 109,139 (16.9%) who had received acarbose treatment were analyzed for CVD risk. Those with CVD followed by acarbose therapy were also subjected to analysis. Result. During 7 years of follow-up, 5,081 patients (4.7%) developed CVD. The crude hazard ratio (HR) and adjusted HR were 0.66 and 0.99, respectively. The adjusted HR of CVD was 1.19, 0.70, and 0.38 when the duration of acarbose use was <12 months, 12–24 months, and >24 months, respectively. Adjusted HR was 1.14, 0.64, and 0.41 with acarbose cumulative doses <54,750 mg, 54,751 to 109,500 mg, and >109,500 mg, respectively. Conclusion. In patients with type 2 diabetes without preexisting CVD, treatment with acarbose showed a transient increase in incidence of CVD in the initial 12 months followed by significant reductions of CVD in prolonged acarbose users. After the first CVD events, continuous use of acarbose revealed neutral effect within the first 12 months. The underlying mechanisms require further investigations.
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影响因子：
3.2
作者：
Wang, Jun-Sing;Lin, Shi-Dou;Sheu, Wayne Huey-Herng
通讯作者：
Sheu, Wayne Huey-Herng
影响因子：
8
作者：
Wang, J. -S.;Tu, S. -T.;Sheu, Wayne H. -H.
通讯作者：
Sheu, Wayne H. -H.
影响因子：
39.3
作者：
Hanefeld, M;Cagatay, M;Rupp, M
通讯作者：
Rupp, M
影响因子：
5.8
作者：
Rachmani, R;Bar-Dayan, Y;Ravid, M
通讯作者：
Ravid, M
影响因子：
5.1
作者：
Scott, R;Lintott, CJ;Welborn, T
通讯作者：
Welborn, T