Influence of aspirin and indomethacin on variability of alveolar hypoxic vasoconstriction.
Influence of aspirin and indomethacin on variability of alveolar hypoxic vasoconstriction.
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阿司匹林和吲哚美辛对肺泡缺氧血管收缩变异性的影响。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
J. Slate
中科院分区：
文献类型：
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作者：
C. Hales;E. Rouse;J. Slate
肺泡低氧引起肺血管收缩，但肺泡低氧血管收缩(AHV)的强度即使在同一物种内也是不同的。本文观察了环氧合酶抑制剂阿司匹林和吲哚美辛对弱AHV犬和强AHV犬的影响。双腔气管导管允许一侧肺以氮气作为肺泡低氧刺激进行通风，而另一肺以氧气进行通风以维持全身氧合。用氙气-133和外部计数器测量每个肺的血流灌注量。在弱反应中，阿司匹林和消炎痛均可使AHV增加4倍(P<0.01)，而对强反应则无明显影响。环氧合酶抑制剂也能增强离体肺对肺泡缺氧和前列腺素F2pha的反应性，但对血管紧张素II和去甲肾上腺素无反应。阿司匹林增强的AHV不能通过阻断血管紧张素II受体或阿尔法受体而减少。综上所述，完整或分离的犬肺中弱的AHV可能是由于前列腺素或前列环素血管扩张剂过量所致。
Alveolar hypoxia induces pulmonary vasoconstriction but the strength of alveolar hypoxic vasoconstriction (AHV) is variable even within the same species. The influence of aspirin and indomethacin, cyclo-oxygenase inhibitors, was examined in two groups of dogs, those with weak AHV and those with vigorous AHV. A double-lumen endotracheal tube allowed ventilation of one lung with nitrogen as an alveolar hypoxic stimulus and ventilation of the other lung with O2 to maintain systemic oxygenation. Perfusion to each lung was measured with xenon-133 and external counters. In weak reactors both aspirin and indomethacin induced fourfold enhancement of AHV (P less than 0.01), whereas no significant influence on vigorous reactors was noted. Cyclo-oxygenase inhibitors also produced enhanced reactivity in the isolated lung to alveolar hypoxia and prostaglandin F2alpha but not to angiotensin II and norepinephrine. Aspirin-enhanced AHV in the isolated lung could not be diminished with blockade of angiotensin II receptors or of alpha receptors. In summary, weak AHV in intact or isolated dog lung may be due to an excess of a prostaglandin or prostacyclin vasodilator.